Keflex

Cephalexin, the active ingredient in Keflex, is a first‑generation cephalosporin presented as an oral tablet for systemic use. It treats bacterial infections of the skin, respiratory tract, urinary tract and bone in adults and children as prescribed.

GNH USA supplies Keflex as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Keflex (cephalexin) is a first‑generation cephalosporin used to treat infections caused by susceptible bacteria.

- Skin infections: resolves cellulitis, impetigo and other bacterial skin conditions. - Respiratory tract infections: treats acute bacterial sinusitis, pharyngitis and bronchitis. - Urinary tract infections: eradicates uncomplicated cystitis caused by susceptible organisms. - Bone and joint infections: assists in managing osteomyelitis and septic arthritis when indicated.

Adverse reactions to cephalexin can range from mild to severe and may require medical attention.

Common Side Effects: - Nausea: mild gastrointestinal upset. - Diarrhea: loose stools, often self‑limiting. - Abdominal pain: cramping or discomfort. - Rash: mild skin erythema or itching. - Headache: transient tension‑type headache. - Vaginal candidiasis: yeast overgrowth in some patients.

Serious or Rare Side Effects: - Anaphylaxis: severe allergic reaction with airway compromise. - Stevens‑Johnson syndrome: rare but life‑threatening skin eruption. - Clostridioides difficile colitis: severe diarrhea due to bacterial overgrowth. - Hemolytic anemia: destruction of red blood cells. - Liver enzyme elevation: potential hepatic involvement. - Severe neutropenia: marked reduction in white blood cells.

Before prescribing cephalexin, clinicians should consider patient‑specific factors and potential risks. - Allergy assessment: avoid if known hypersensitivity to cephalosporins or penicillins. - Renal function: adjust dose in patients with impaired kidney function. - Pregnancy and lactation: use only if clearly needed after risk‑benefit evaluation. - Drug interactions: review concomitant medications for possible interactions. - Storage: Store below 25°C: keep in the original pack, protect from moisture.

Cephalexin may interact with other medicines, altering efficacy or safety.

Major Interactions (Avoid): - Probenecid: reduces renal excretion, increasing cephalexin levels. - Warfarin: may enhance anticoagulant effect, raising bleeding risk.

Moderate Interactions (Monitor Closely): - Oral contraceptives: possible reduction in hormonal efficacy. - Metformin: may increase plasma concentration, monitor renal function. - Aminoglycosides: combined nephrotoxicity potential. - Antacids containing aluminum or magnesium: may decrease absorption if taken simultaneously.