Keflex

Cefalexin, the active ingredient in Keflex, is a first‑generation cephalosporin presented as an oral tablet for oral use. It treats a range of bacterial infections and is commonly prescribed for adults and children when indicated by a healthcare professional.

GNH USA supplies Keflex as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Cefalexin is a broad‑spectrum antibiotic that targets bacterial infections of several organ systems.

- Skin and soft‑tissue infections: helps eradicate common Gram‑positive organisms causing cellulitis, impetigo and wound infections. - Respiratory tract infections: effective against streptococcal and staphylococcal pathogens in conditions such as acute bronchitis and sinusitis. - Urinary tract infections: clears susceptible Escherichia coli and other uropathogens causing cystitis. - Bone and joint infections: used as part of combination therapy for osteomyelitis and septic arthritis caused by susceptible bacteria.

Cefalexin may cause a range of adverse reactions, from mild to severe.

Common Side Effects: - Nausea: mild gastrointestinal upset occurring in many patients. - Diarrhea: loose stools that may be self‑limiting. - Rash: skin redness or mild itching. - Headache: transient headache without neurological signs.

Serious or Rare Side Effects: - Anaphylaxis: severe allergic reaction with breathing difficulty and swelling. - Clostridioides difficile colitis: severe diarrhea due to intestinal flora disruption. - Hepatotoxicity: elevated liver enzymes or jaundice in rare cases.

Before using Cefalexin, consider the following safety measures.

- Allergy assessment: avoid if the patient has a known cephalosporin or penicillin hypersensitivity. - Renal function: adjust dose in patients with impaired kidney function. - Pregnancy and lactation: discuss risks with a healthcare provider before use. - Concomitant antibiotics: monitor for potential antagonistic effects. - Store at ambient temperature: keep below 25°C, retain in original packaging, protect from moisture.

Cefalexin can interact with several medicines, requiring attention to avoid reduced efficacy or increased toxicity.

Major Interactions (Avoid): - Probenecid: may increase cefalexin plasma concentrations, raising toxicity risk. - Oral anticoagulants: can enhance anticoagulant effect, necessitating INR monitoring.

Moderate Interactions (Monitor Closely): - Metformin: may increase metformin levels; monitor renal function and blood glucose. - Oral contraceptives: potential reduction in contraceptive effectiveness; advise backup methods. - Antacids containing aluminum or magnesium: may decrease cefalexin absorption; separate dosing by at least 2 hours.