Keflex

Cefalexin, the active ingredient in Keflex, is a first‑generation cephalosporin presented as an oral tablet for oral use. It treats bacterial infections of the skin, respiratory tract, urinary system and bone in adults and children as prescribed by a healthcare professional.

GNH USA supplies Keflex as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Cefalexin (Keflex) is a cephalosporin antibiotic that targets bacterial cell‑wall synthesis, making it effective for several common infection types.

- Skin and soft‑tissue infections: resolves cellulitis, impetigo and wound infections. - Respiratory tract infections: treats acute bronchitis, sinusitis and community‑acquired pneumonia. - Urinary tract infections: clears cystitis and uncomplicated pyelonephritis. - Bone and joint infections: used for osteomyelitis and septic arthritis.

Cefalexin may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects: - Nausea: mild stomach upset. - Diarrhea: loose stools, sometimes watery. - Abdominal pain: cramping or discomfort. - Vomiting: occasional emesis. - Rash: mild skin redness or itching. - Headache: transient head pain.

Serious or Rare Side Effects: - Anaphylaxis: severe allergic reaction with breathing difficulty. - Stevens‑Johnson syndrome: serious skin and mucous membrane disorder. - Clostridioides difficile‑associated diarrhea: severe colitis. - Blood dyscrasias: neutropenia, thrombocytopenia, or anemia. - Liver enzyme elevation: hepatitis or jaundice.

Before prescribing cefalexin, clinicians should consider several precautionary measures to ensure safe use.

- Assess allergy history: avoid in patients with known cephalosporin or penicillin hypersensitivity. - Evaluate renal function: dose adjustment may be needed in impaired clearance. - Monitor for superinfection: prolonged use can lead to fungal overgrowth. - Use cautiously in pregnancy: only if benefits outweigh risks. - Observe for gastrointestinal effects: advise patients to stay hydrated. - Store at room temperature: keep in the original container, protect from moisture and heat.

Cefalexin can interact with other medicines, influencing its efficacy or safety.

Major Interactions (Avoid): - Methotrexate: reduced clearance may increase toxicity. - Cytotoxic agents (e.g., cyclophosphamide): heightened myelosuppression risk.

Moderate Interactions (Monitor Closely): - Probenecid: decreases renal excretion, raising cefalexin plasma levels. - Warfarin: may enhance anticoagulant effect, requiring INR monitoring. - Oral contraceptives: possible reduction in effectiveness, advise backup contraception.