Karpin

Amlodipine, the active ingredient in Karpin, is a calcium channel blocker presented as an oral tablet for oral use. It is used to treat hypertension and chronic stable angina in adult patients.\n\nGNH India supplies Karpin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Amlodipine acts on the vascular smooth muscle and cardiac muscle to lower blood pressure and relieve angina.\n\nHypertension: reduces systemic vascular resistance, helping to achieve target blood pressure levels.\nChronic stable angina: improves coronary blood flow, decreasing the frequency and severity of chest pain episodes.

Amlodipine may cause a range of adverse reactions, from mild to severe.\n\nCommon Side Effects:\n- Headache\n- Peripheral edema\n- Flushing\n- Dizziness\n- Fatigue\n- Palpitations\n\nSerious or Rare Side Effects:\n- Severe hypotension\n- Myocardial infarction\n- Hepatic dysfunction\n- Arrhythmias\n- Stevens‑Johnson syndrome\n- Angioedema

Before initiating therapy, consider patient‑specific factors and monitor for adverse events.\n\nMonitor blood pressure: ensure adequate control without excessive hypotension.\nAssess cardiac function: avoid use in patients with severe aortic stenosis or cardiogenic shock.\nReview concomitant medications: watch for additive hypotensive effects.\nUse caution in hepatic impairment: dose adjustment may be required.\nAvoid abrupt discontinuation: taper to prevent rebound hypertension.\nStore at room temperature: keep in the original pack, protect from moisture.

Amlodipine can interact with several drug classes, requiring careful management.\n\nMajor Interactions (Avoid):\n- Simvastatin >20 mg: increased risk of myopathy.\n- Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): elevated amlodipine levels.\n- Rifampin or other CYP3A4 inducers: reduced efficacy.\n- Other antihypertensives causing additive hypotension.\n- Grapefruit juice: may increase plasma concentration.\n\nModerate Interactions (Monitor Closely):\n- Beta‑blockers: potential for excessive blood pressure reduction.\n- Diuretics: may enhance orthostatic effects.\n- NSAIDs: can blunt antihypertensive response.\n- Lithium: monitor serum levels.\n- Digoxin: watch for bradycardia.