GNH USA

Europe — EMA

Karbolan

GNH USA supplies Karbolan (Urea), a keratolytic for hyperkeratosis, ichthyosis, dry skin and psoriasis. Request a quote for global supply to qualified buyers.

Urea

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What is Urea?

Urea, the active ingredient in Karbolan, is a keratolytic presented as a topical preparation for skin use. It helps to soften and hydrate hyperkeratotic lesions, making it useful for conditions such as hyperkeratosis, ichthyosis, dry skin and psoriasis in adults and children. GNH USA supplies Karbolan as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Urea used for?

Karbolan is a topical keratolytic used to manage disorders characterized by excessive keratin buildup.

Hyperkeratosis: reduces thickness and scaling of hyperkeratotic plaques. Ichthyosis: improves skin smoothness and reduces scaling. Dry skin: enhances hydration and softness of rough skin. Psoriasis: helps to soften plaques and lessen scaling.

What are the side effects of Urea?

Karbolan may cause local skin reactions, most of which are mild and reversible.

Common Side Effects: - Skin irritation or burning sensation. - Itching or mild pruritus. - Redness or erythema at the application site. - Dryness or peeling of the treated skin.

Serious or Rare Side Effects: - Allergic contact dermatitis with swelling or vesiculation. - Severe urticaria or widespread rash. - Blistering or extensive skin breakdown requiring medical attention.

What precautions apply to Urea?

Before using Karbolan, consider the following safety measures.

Pregnancy: consult a healthcare professional before use. Breastfeeding: use with caution and under medical advice. Skin integrity: avoid application on open wounds or severely damaged skin. Allergy: discontinue immediately if signs of allergic reaction appear. Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

What does Urea interact with?

Karbolan may interact with other topical agents; monitor for increased irritation.

Major Interactions (Avoid): - Concurrent use of strong topical steroids may heighten skin irritation. - Combination with other keratolytics such as salicylic acid can cause excessive peeling.

Moderate Interactions (Monitor Closely): - Occlusive dressings may increase systemic absorption. - Alcohol‑based cleansers can enhance dryness when used together. - Phototherapy may increase photosensitivity of treated areas.

Frequently asked questions

What conditions is Karbolan used for?+
Karbolan is a topical keratolytic indicated for the management of hyperkeratosis, ichthyosis, dry skin and psoriasis. It helps to soften thickened skin, reduce scaling and improve overall skin texture in these dermatologic conditions.
How does the active ingredient urea work in Karbolan?+
Urea works by breaking hydrogen bonds within keratin, promoting keratinolysis and increasing water retention in the stratum corneum. This dual action softens hyperkeratotic plaques, enhances skin hydration and facilitates the removal of excess keratin.
What is the usual dose of Karbolan?+
The dosage of Karbolan is determined by the prescribing healthcare professional based on the specific condition, severity and patient characteristics. The prescriber will advise the appropriate amount and frequency of topical application.
Is Karbolan safe to use during pregnancy or breastfeeding?+
Karbolan is classified as an OTC topical product. While systemic exposure is minimal, pregnant or breastfeeding individuals should consult their healthcare provider before using it to ensure it is appropriate for their situation.
How do I order Karbolan from GNH USA?+
To order Karbolan, submit an enquiry on the product page at gnh-usa.com specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.
How does Karbolan compare with other keratolytic agents?+
Karbolan’s urea‑based formulation offers both keratolytic and humectant properties, which can be gentler than stronger acids like salicylic acid. It provides effective softening of hyperkeratotic lesions while maintaining skin hydration, making it suitable for patients who need a milder yet effective option.
What are the storage requirements for Karbolan?+
Karbolan should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed when not in use.
How is Karbolan applied?+
Karbolan is applied topically to the affected skin area. Clean and gently dry the skin, then spread a thin layer of the product as directed by the prescriber, usually once or twice daily, and allow it to absorb before covering the area.
What are the most serious risks associated with Karbolan?+
The most serious risks include allergic contact dermatitis, severe skin swelling, blistering or widespread rash. If any of these reactions occur, discontinue use immediately and seek medical attention.
Who should not use Karbolan?+
Karbolan should not be used on broken or infected skin, in individuals with a known hypersensitivity to urea or any excipients in the formulation, and it is contraindicated in patients where a healthcare professional advises against its use.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.

Product details

Drug
Urea
Route
Topical
Manufacturer
Evolan Pharma Ab
Origin
EU

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