GNH USA

Europe — EMA

Kapake

GNH USA supplies Kapake (Paracetamol and Codeine), an analgesic for mild to moderate pain and fever, hospitals and pharmacies. Request a quote for supply.

Paracetamol, Codeine Phosphate Hemihydrate

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What is Paracetamol, Codeine Phosphate Hemihydrate?

Paracetamol and Codeine Phosphate Hemihydrate, the active ingredients in Kapake, are analgesics presented as an oral tablet for oral use. They treat mild to moderate pain and fever in adult patients. GNH USA supplies Kapake as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Paracetamol, Codeine Phosphate Hemihydrate used for?

Kapake combines paracetamol and codeine to address pain and fever pathways. - Mild to moderate pain: provides effective analgesia for conditions such as musculoskeletal discomfort. - Fever: reduces elevated body temperature associated with infectious or inflammatory states. - Post‑operative pain: alleviates discomfort after surgical procedures. - Dental pain: controls pain following dental extractions or procedures. - Headache: relieves tension‑type or mild migraine headaches.

What are the side effects of Paracetamol, Codeine Phosphate Hemihydrate?

Common side effects are generally mild and transient. Common Side Effects: - Nausea - Constipation - Drowsiness - Dizziness - Dry mouth - Mild skin rash

Serious or Rare Side Effects: - Respiratory depression - Severe allergic reaction (anaphylaxis) - Hepatotoxicity in overdose - Seizures - Severe hypotension - Dependence or addiction potential

What precautions apply to Paracetamol, Codeine Phosphate Hemihydrate?

Kapake should be used with caution in specific clinical situations. - Liver function assessment: evaluate hepatic status before initiating therapy. - Respiratory conditions: avoid in patients with severe respiratory depression. - CNS depressants: use cautiously with other sedatives or alcohol. - Dependence risk: monitor for signs of misuse or addiction. - Duration of therapy: limit use to the shortest effective period. - Store at ambient temperature: keep in the original pack, protect from moisture.

What does Paracetamol, Codeine Phosphate Hemihydrate interact with?

Kapake may interact with several drug classes, requiring careful management. Major Interactions (Avoid): - Alcohol: potentiates central nervous system depression. - Benzodiazepines or other CNS depressants: risk of profound sedation. - MAO inhibitors: can increase opioid effects. - Other opioid analgesics: risk of additive respiratory depression. - Strong CYP2D6 inhibitors (e.g., fluoxetine): may alter codeine metabolism.

Moderate Interactions (Monitor Closely): - Antihistamines: may increase drowsiness. - SSRIs or SNRIs: potential for serotonin syndrome. - Antacids: may affect absorption. - Diuretics: monitor blood pressure changes. - Antihypertensives: possible additive hypotensive effect.

Frequently asked questions

What is Kapake used for?+
Kapake is a prescription oral tablet that combines paracetamol and codeine phosphate hemihydrate to relieve mild to moderate pain and to reduce fever. It is commonly prescribed for conditions such as musculoskeletal pain, postoperative discomfort, dental pain, and fever associated with infections.
How does paracetamol and codeine work in Kapake?+
Paracetamol provides analgesic and antipyretic effects by centrally inhibiting cyclo‑oxygenase enzymes, which reduces prostaglandin synthesis. Codeine acts as a μ‑opioid receptor agonist, altering pain perception in the central nervous system. The two agents work together to enhance overall pain relief and fever control.
What is the usual dose of Kapake?+
The appropriate dose of Kapake is determined by the prescribing healthcare professional based on the patient’s age, weight, clinical condition, and response to therapy. Patients should follow the prescriber’s instructions and never exceed the recommended amount.
Is Kapake safe to use during pregnancy or breastfeeding?+
Safety of Kapake in pregnancy or while breastfeeding has not been fully established. Healthcare providers should evaluate the potential benefits against possible risks before prescribing it to pregnant or nursing women. Women should discuss any concerns with their physician.
How do I order Kapake from GNH USA?+
To order Kapake, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.
How does Kapake compare with other analgesics?+
Kapake offers a combination of paracetamol and codeine, providing both non‑opioid and opioid analgesia in a single tablet. Compared with paracetamol alone, it adds stronger pain relief but also carries a higher risk of opioid‑related side effects. It is an alternative to other codeine‑containing products when a dual mechanism is desired.
What are the storage requirements for Kapake?+
Kapake should be stored at ambient temperature, below 25 °C, in its original packaging. Protect the tablets from moisture and direct sunlight to maintain potency and stability throughout its shelf life.
How is Kapake administered?+
Kapake is taken orally with a glass of water. It may be taken with or without food, but patients should follow the prescriber’s guidance regarding timing relative to meals to minimize gastrointestinal discomfort.
What are the most serious risks associated with Kapake?+
Serious risks include respiratory depression, severe allergic reactions such as anaphylaxis, hepatotoxicity in cases of overdose, and the potential for dependence or addiction with prolonged use. Patients should seek immediate medical attention if they experience difficulty breathing, rash, or signs of liver injury.
Who should not use Kapake?+
Kapake should be avoided in individuals with known hypersensitivity to paracetamol, codeine, or any excipients, in patients with severe respiratory depression, uncontrolled asthma, or significant liver disease, and in anyone taking prohibited concomitant medications listed as major interactions.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Paracetamol, Codeine Phosphate Hemihydrate
Route
Oral Use
Manufacturer
Athlone Pharmaceuticals Limited
Origin
EU

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