Kafenac

Aceclofenac, the active ingredient in Kafenac, is a nonsteroidal anti-inflammatory drug (NSAID) presented as an oral tablet for oral use. It treats inflammatory and painful musculoskeletal conditions such as osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute musculoskeletal pain and dental pain, providing analgesic and anti‑inflammatory effects.

GNH USA supplies Kafenac as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Aceclofenac is indicated for inflammatory musculoskeletal disorders and related pain conditions.

- Osteoarthritis: reduces joint pain and improves functional mobility. - Rheumatoid arthritis: alleviates joint inflammation and swelling. - Ankylosing spondylitis: relieves spinal pain and stiffness. - Acute musculoskeletal pain: provides rapid analgesia for injuries or strains. - Dental pain: controls postoperative dental discomfort.

Adverse reactions may occur with Aceclofenac use and are categorized by frequency and severity.

Common Side Effects: - Gastrointestinal discomfort or dyspepsia. - Nausea or vomiting. - Headache. - Dizziness. - Mild skin rash. - Elevated liver enzymes.

Serious or Rare Side Effects: - Gastrointestinal ulceration or bleeding. - Severe hepatic injury. - Acute renal impairment. - Life‑threatening skin reactions such as Stevens‑Johnson syndrome. - Anaphylactic shock. - Cardiovascular events including myocardial infarction.

Before prescribing Aceclofenac, clinicians should consider several safety measures.

- Assess gastrointestinal risk: evaluate history of ulcers or bleeding. - Monitor liver function: check hepatic enzymes periodically. - Evaluate renal function: adjust use in patients with impaired kidneys. - Use the lowest effective dose: limit duration to the shortest necessary period. - Avoid in known hypersensitivity: discontinue if allergic reactions develop. - Store at room temperature: keep in the original pack, protect from moisture.

Aceclofenac can interact with other medicines, requiring careful management.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): increased bleeding risk. - Other NSAIDs or aspirin: additive gastrointestinal toxicity. - Corticosteroids: heightened risk of ulceration. - Selective serotonin reuptake inhibitors (SSRIs): potential for bleeding. - ACE inhibitors or ARBs: may reduce renal perfusion.

Moderate Interactions (Monitor Closely):\n- Diuretics: possible reduction in antihypertensive effect. - Lithium: increased serum lithium levels. - Methotrexate: reduced clearance leading to toxicity.