Kadeflora

Lactobacillus plantarum P 17630, the active ingredient in Kadeflora, is a probiotic presented as a vaginal formulation for intravaginal use. It helps restore a healthy vaginal microbiota by colonising the vagina with beneficial lactobacilli, thereby supporting normal pH and inhibiting pathogenic organisms.

GNH USA supplies Kadeflora as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with distribution originating from the European Union market. The company ensures quality compliance with EU manufacturing standards and provides global logistics support.

Kadeflora is a vaginal probiotic that acts on the vaginal microbiome to promote a balanced bacterial environment.

- Bacterial vaginosis: helps re‑establish lactobacilli dominance and may reduce recurrence after standard therapy. - Post‑antibiotic vaginal dysbiosis: restores normal flora following antibiotic treatment, supporting pH normalization. - Recurrent vulvovaginal candidiasis: may aid in maintaining a protective lactobacilli population to lower yeast overgrowth risk.

Adverse reactions to Kadeflora are generally mild and related to local vaginal exposure.

Common Side Effects: - Vaginal irritation: mild burning or stinging sensation. - Increased vaginal discharge: thin, white or off‑color discharge. - Itching or pruritus: mild localized itching. - Sensation of fullness: feeling of pressure in the vagina.

Serious or Rare Side Effects: - Allergic reaction: rash, swelling, or hives. - Severe vaginal infection: signs of worsening infection despite use. - Systemic infection: rare cases of bacteremia in immunocompromised patients. - Anaphylaxis: rapid onset of breathing difficulty, hypotension.

Before using Kadeflora, consider the following precautions to ensure safe and effective use.

- Pregnancy: safety has not been established; consult a healthcare professional before use. - Breastfeeding: limited data are available; discuss with a physician. - Immunocompromised patients: use with caution as rare systemic infection has been reported. - Concomitant antibiotic therapy: antibiotics may reduce probiotic efficacy; timing may need adjustment. - Store at ambient temperature: keep the product in its original packaging, protect from moisture and direct sunlight.

Kadeflora may interact with other agents that affect the vaginal microbiome or immune response.

Major Interactions (Avoid): - Systemic antibiotics: may eradicate the probiotic strain, negating its benefit. - Antifungal agents: concurrent use can diminish colonisation of Lactobacillus plantarum.

Moderate Interactions (Monitor Closely): - Immunosuppressive drugs: increased risk of opportunistic infection; monitor patient closely. - Hormonal contraceptives: no direct interaction, but hormonal changes can affect vaginal flora. - Vaginal douches or antiseptics: may disrupt probiotic colonisation; advise limited use.