GNH USA

Europe — EMA

Kabiven

GNH USA supplies Kabiven (Amino Acid Solution), a parenteral nutrition product for patients unable to receive oral or enteral intake.

Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin

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What is Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin?

Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, and Serine, the active ingredients in Kabiven, are an amino acid solution presented as an intravenous solution for parenteral nutrition use. It provides essential amino acids to patients who cannot receive adequate oral or enteral intake.

GNH USA supplies Kabiven as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

What is Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin used for?

Kabiven is an amino acid solution used in parenteral nutrition to meet protein and metabolic needs.

Parenteral nutrition for patients with inadequate oral or enteral intake: Supplies essential amino acids to support protein synthesis when enteral feeding is not possible. Critical care or postoperative patients: Helps meet increased protein requirements during acute illness or after surgery. Severe malnutrition: Contributes to nutritional rehabilitation by providing a balanced amino acid profile.

What are the side effects of Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin?

Kabiven may be associated with a range of infusion‑related reactions.

Common Side Effects: - Hyperglycemia: elevated blood glucose levels during infusion. - Electrolyte imbalance: shifts in potassium, sodium, or calcium concentrations. - Phlebitis: inflammation of the vein at the infusion site. - Infusion site reactions: redness, swelling, or discomfort.

Serious or Rare Side Effects: - Anaphylactic reaction: severe allergic response requiring immediate medical attention. - Metabolic acidosis: significant drop in blood pH due to acid accumulation. - Hyperammonemia: elevated ammonia levels, especially in patients with hepatic impairment.

What precautions apply to Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin?

When using Kabiven, clinicians should observe several safety measures.

Renal impairment: adjust infusion volume and monitor renal function. Hepatic dysfunction: monitor ammonia and liver enzymes. Electrolyte monitoring: check serum electrolytes regularly. Hyperglycemia risk: measure blood glucose during therapy. Compatibility: ensure proper dilution and avoid mixing with incompatible solutions. Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

What does Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin interact with?

Kabiven can interact with other intravenous agents and systemic medications.

Major Interactions (Avoid): - Concurrent high‑dose potassium chloride: risk of precipitation. - Calcium‑containing solutions mixed directly: may cause insoluble calcium‑phosphate complexes. - Incompatible drugs (e.g., certain antibiotics) when combined in the same line.

Moderate Interactions (Monitor Closely): - Loop diuretics: may increase electrolyte loss. - Insulin therapy: may augment hypoglycemia risk. - Other parenteral nutrition components: monitor total nutrient and fluid load.

Frequently asked questions

What is Kabiven used for?+
Kabiven is an intravenous amino acid solution used as part of parenteral nutrition to provide essential amino acids to patients who cannot obtain adequate nutrition through oral or enteral routes, such as those in critical care, postoperative recovery, or severe malnutrition.
How does the amino acid mixture in Kabiven work?+
The amino acids in Kabiven are delivered directly into the bloodstream, making them immediately available for protein synthesis, energy production, and metabolic processes. This bypasses the gastrointestinal tract and helps maintain nitrogen balance and tissue repair in patients unable to eat or absorb nutrients.
What is the usual dose of Kabiven?+
The dose of Kabiven is individualized by the prescribing clinician based on the patient’s weight, metabolic needs, and clinical condition. Healthcare professionals calculate the appropriate volume and concentration to meet the patient’s protein and caloric requirements.
Is Kabiven safe to use during pregnancy or breastfeeding?+
Safety data for Kabiven in pregnancy and lactation are limited. It should only be used if the potential benefits outweigh any potential risks, and the decision must be made by a qualified healthcare provider after careful assessment.
How do I order Kabiven from GNH USA?+
To order Kabiven, submit an enquiry on the product page at gnh-usa.com with the required quantity. GNH USA works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and import documentation.
How does Kabiven compare with other parenteral amino acid products?+
Kabiven offers a comprehensive blend of essential and non‑essential amino acids in a single intravenous formulation, matching the amino acid profile recommended for adult parenteral nutrition. Compared with products that provide separate amino acid modules, Kabiven simplifies preparation and reduces the risk of dosing errors.
What are the storage and handling requirements for Kabiven?+
Kabiven must be stored refrigerated at 2‑8 °C, protected from light, and should never be frozen or shaken. Before use, allow the solution to reach room temperature if required, and inspect for particulate matter or discoloration.
How is Kabiven administered?+
Kabiven is administered intravenously, typically through a central venous catheter or a peripheral line using an infusion pump. The infusion rate is set by the clinician according to the prescribed volume and the patient’s tolerance, with regular monitoring of vital signs and laboratory parameters.
What are the most serious risks associated with Kabiven?+
Serious risks include anaphylactic reactions, metabolic acidosis, and hyperammonemia, especially in patients with liver dysfunction. Prompt recognition of symptoms such as difficulty breathing, rapid heart rate, or altered mental status is essential, and immediate medical intervention should be initiated.
Who should not receive Kabiven?+
Kabiven should be avoided in patients with known hypersensitivity to any of its amino acid components, severe renal or hepatic failure where amino acid clearance is compromised, and in those where compatible intravenous solutions cannot be ensured.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin
Route
Intravenous Use
Manufacturer
Fresenius Kabi Ab
Origin
EU