GNH USA

Europe — EMA

Kabiven

GNH USA supplies Kabiven (Amino Acid Solution), a parenteral nutrition product for patients unable to receive enteral feeding.

Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin

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What is Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin?

Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serine, the active ingredients in Kabiven, are an amino acid solution presented as an intravenous solution for parenteral use. It provides essential amino acids to patients who cannot receive enteral nutrition.

GNH USA supplies Kabiven as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

What is Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin used for?

Kabiven is used in the field of parenteral nutrition to address protein and nitrogen needs when oral or enteral feeding is not possible. - Inadequate oral or enteral intake: supplies a complete profile of essential amino acids to meet nutritional requirements. - Critical illness or postoperative care: supports protein synthesis and helps preserve lean body mass. - Contraindicated enteral feeding: provides an alternative route for delivering amino acids in malnourished patients.

What are the side effects of Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin?

Kabiven may be associated with a range of infusion‑related reactions.

Common Side Effects: - Hyperglycaemia: elevated blood glucose levels during infusion. - Electrolyte disturbances: changes in potassium, sodium or calcium concentrations. - Infusion site reactions: erythema, pain or phlebitis at the catheter site. - Nausea or vomiting: gastrointestinal discomfort during administration. - Fever or chills: transient temperature rise.

Serious or Rare Side Effects: - Anaphylactic reaction: severe hypersensitivity requiring immediate medical intervention. - Metabolic acidosis: significant pH reduction in blood. - Hepatic dysfunction: abnormal liver enzyme elevations. - Renal impairment: worsening kidney function in susceptible patients. - Thrombophlebitis: clot formation with vein inflammation.

What precautions apply to Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin?

When using Kabiven, clinicians should observe several safety measures. - Assess renal function: adjust dosage if creatinine clearance is reduced. - Monitor electrolytes: check serum potassium, sodium and calcium regularly. - Evaluate nitrogen balance: ensure adequate but not excessive protein provision. - Adjust infusion rate: reduce speed in hemodynamically unstable patients. - Use aseptic technique: prevent catheter‑related infections. - Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

What does Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin interact with?

Kabiven can interact with other intravenous solutions and medications.

Major Interactions (Avoid): - Calcium‑containing solutions: risk of precipitation with amino acids. - High‑dose insulin therapy: may precipitate severe hypoglycaemia. - Certain antibiotics (e.g., aminoglycosides): potential for reduced efficacy when mixed.

Moderate Interactions (Monitor Closely): - Loop diuretics: may exacerbate electrolyte shifts. - Renal replacement therapy: may require dose adjustment of amino acid infusion. - Steroid therapy: can increase protein catabolism, affecting nutritional goals.

Frequently asked questions

What is Kabiven used for?+
Kabiven is an intravenous amino acid solution used as part of parenteral nutrition. It provides essential amino acids to patients who cannot receive adequate nutrition through oral or enteral routes, such as those in critical care, postoperative settings, or with severe malnutrition.
How does the amino acid mixture in Kabiven work?+
The amino acids in Kabiven enter the bloodstream directly, serving as building blocks for protein synthesis and replenishing nitrogen stores. This supports tissue repair, maintains lean body mass, and sustains metabolic functions when normal dietary intake is unavailable.
What is the usual dose of Kabiven?+
The dose of Kabiven is individualized by the prescribing clinician based on the patient’s weight, clinical condition, renal and hepatic function, and overall nutritional goals. No fixed regimen is provided; the healthcare professional determines the appropriate infusion rate and volume.
Is Kabiven safe to use during pregnancy or breastfeeding?+
Safety data for Kabiven in pregnancy and lactation are limited. The product should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision must be made by the treating physician.
How do I order Kabiven from GNH USA?+
To order Kabiven, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and import documentation.
How does Kabiven compare with other parenteral nutrition amino acid products?+
Kabiven offers a balanced blend of ten essential amino acids in a single intravenous formulation, meeting European pharmacopeial standards. Compared with multi‑component amino acid kits, Kabiven simplifies preparation and reduces compatibility concerns, while delivering comparable nutritional support for patients requiring total parenteral nutrition.
What are the storage and handling requirements for Kabiven?+
Kabiven must be stored at 2‑8 °C, protected from light, and must not be frozen or shaken. Keep the solution in its original container until use, and discard any product that appears discoloured or contains particles.
How is Kabiven administered to patients?+
Kabiven is administered intravenously, typically via a central venous catheter or a peripheral line using an infusion pump. The infusion rate is set by the clinician according to the prescribed daily amino acid requirement and patient tolerance.
What are the most serious risks associated with Kabiven?+
Serious risks include anaphylactic reactions, metabolic acidosis, hepatic dysfunction, renal impairment, and thrombophlebitis. Patients should be closely monitored for signs of hypersensitivity, changes in blood chemistry, and any vascular complications during and after infusion.
Who should not receive Kabiven?+
Kabiven is contraindicated in patients with known hypersensitivity to any of its amino acid components, those with severe metabolic disorders that preclude amino acid administration, and individuals with uncontrolled electrolyte imbalances that cannot be corrected before infusion.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin
Route
Intravenous Use
Manufacturer
Fresenius Kabi Ab
Origin
EU