GNH USA

Europe — EMA

Kabiven

GNH USA supplies Kabiven (Valine), a parenteral nutrition for patients unable to receive enteral feeding and for postoperative or critically ill support.

Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin

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What is Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin?

Valine, the active ingredient in Kabiven, is a parenteral nutrition presented as a solution for injection for intravenous use. It provides a balanced mixture of essential amino acids to support protein synthesis and maintain nitrogen balance in patients who cannot receive enteral feeding, such as those postoperative, trauma, or critically ill.

GNH USA supplies Kabiven as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres and clinics worldwide.

What is Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin used for?

Kabiven is employed in parenteral nutrition to meet protein and nitrogen requirements across several clinical scenarios.

- Patients unable to receive enteral feeding: supplies essential amino acids to sustain nutrition. - Post‑operative, trauma or critically ill patients: supports recovery by providing building blocks for tissue repair. - Catabolic states: helps maintain nitrogen balance and prevents muscle wasting.

What are the side effects of Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin?

Kabiven may be associated with infusion‑related and metabolic adverse reactions.

Common Side Effects: - Phlebitis or infusion site erythema - Mild hypernatremia - Transient metabolic alkalosis - Elevated serum urea nitrogen - Mild hyperglycemia - Temporary increase in serum triglycerides

Serious or Rare Side Effects: - Hypersensitivity reactions including anaphylaxis - Severe electrolyte disturbances (e.g., hyperkalemia, hypocalcemia) - Hyperammonemia - Acute renal insufficiency - Severe metabolic acidosis - Pulmonary edema from fluid overload

What precautions apply to Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin?

When using Kabiven, clinicians should observe several safety measures.

- Assess renal function: adjust infusion rate in renal impairment. - Monitor electrolytes: check serum levels regularly during therapy. - Evaluate hepatic status: consider reduced clearance in liver disease. - Use aseptic technique: prevent contamination of the intravenous line. - Avoid in patients with known hypersensitivity to any component of the solution. - Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

What does Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin interact with?

Kabiven can interact with other therapies; awareness of the interaction level guides management.

Major Interactions (Avoid): - Concurrent high‑dose amino acid solutions: may cause osmolar overload and fluid imbalance. - Co‑administration with nephrotoxic drugs: can exacerbate renal stress.

Moderate Interactions (Monitor Closely): - Insulin therapy: amino acids may affect glucose control, requiring dose adjustments. - Diuretics: may alter electrolyte balance, necessitating close monitoring. - Other parenteral nutrition components: compatibility testing is recommended to prevent precipitation.

Frequently asked questions

What is Kabiven used for?+
Kabiven is an amino acid solution for parenteral nutrition. It is administered intravenously to patients who cannot receive enteral feeding, such as those who are postoperative, trauma victims, or critically ill, providing essential building blocks for protein synthesis and nitrogen balance.
How does Valine work in Kabiven?+
Valine, together with the other essential amino acids in Kabiven, serves as a substrate for protein synthesis. By delivering these amino acids directly into the bloodstream, the solution supports cellular repair, maintains nitrogen balance, and helps meet metabolic demands when oral intake is not possible.
What is the usual dose of Kabiven?+
The dose of Kabiven is individualized. The prescribing clinician determines the volume and rate based on the patient’s nutritional needs, weight, renal and hepatic function, and overall clinical condition. No fixed regimen is provided in the product information.
Is Kabiven safe during pregnancy or breastfeeding?+
Safety data for Kabiven in pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision must be made by the treating physician.
How do I order Kabiven from GNH USA?+
To order Kabiven, submit an enquiry on the product page at gnh-usa.com specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and import documentation.
How does Kabiven compare with other amino‑acid parenteral solutions?+
Kabiven offers a balanced blend of ten essential amino acids in a single sterile solution, meeting European pharmacopeia standards. Compared with multi‑component kits, it simplifies preparation, reduces compatibility concerns, and provides consistent amino‑acid ratios, though clinicians may choose alternative formulations based on specific patient requirements.
What are the storage and handling requirements for Kabiven?+
Kabiven must be stored at 2‑8 °C, protected from light, and kept in its original container. Do not freeze or shake the solution. Before use, inspect for particulate matter or discoloration and ensure aseptic handling during preparation and administration.
How is Kabiven administered?+
Kabiven is administered intravenously as a sterile solution for injection. It is typically infused through a dedicated line or compatible infusion set, with the rate adjusted according to the patient’s nutritional prescription and monitored for tolerance and metabolic response.
What are the most serious risks associated with Kabiven?+
Serious risks include hypersensitivity reactions such as anaphylaxis, severe electrolyte disturbances (e.g., hyperkalemia, hypocalcemia), hyperammonemia, and fluid overload leading to pulmonary edema. Prompt recognition and appropriate medical intervention are essential if these events occur.
Who should not use Kabiven?+
Kabiven should be avoided in patients with known hypersensitivity to any of its amino‑acid components, in those with uncontrolled severe electrolyte imbalances, or in individuals where fluid overload poses a high risk. Clinical judgment is required for patients with severe renal or hepatic impairment.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin
Route
Intravenous Use
Manufacturer
Fresenius Kabi Ab
Origin
EU