Europe — EMA
Jeanine (Dienogest, Ethinylestradiol)
GNH USA supplies Jeanine (Dienogest/Ethinylestradiol), a combined oral contraceptive for contraception and menstrual cycle regulation.
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What is Dienogest, Ethinylestradiol?
Dienogest/Ethinylestradiol, the active ingredient in Jeanine, is a combined oral contraceptive presented as an oral tablet for oral use. It is used to prevent pregnancy and to regulate menstrual cycles in women of reproductive age. GNH USA supplies Jeanine as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.
What is Dienogest, Ethinylestradiol used for?
Jeanine, a combined hormonal contraceptive, is indicated for conditions related to reproductive hormone regulation. - Contraception: provides reliable prevention of pregnancy by inhibiting ovulation. - Regulation of menstrual cycles: helps achieve predictable, lighter bleeding patterns. - Management of endometriosis symptoms: reduces menstrual‑related pain and lesion progression.
What are the side effects of Dienogest, Ethinylestradiol?
Adverse reactions may occur with any hormonal contraceptive.
Common Side Effects: - Nausea: mild to moderate stomach upset. - Headache: tension‑type or migraine‑like pain. - Breast tenderness: temporary swelling or discomfort. - Breakthrough bleeding: spotting between periods. - Weight fluctuation: mild fluid retention. - Mood changes: irritability or mild depression.
Serious or Rare Side Effects: - Venous thromboembolism: deep vein thrombosis or pulmonary embolism. - Hypertension: significant increase in blood pressure. - Liver dysfunction: abnormal liver enzymes or cholestasis. - Severe allergic reaction: rash, swelling, or anaphylaxis.
What precautions apply to Dienogest, Ethinylestradiol?
Before prescribing Jeanine, consider the following safety measures. - Contraindications: avoid in women with a history of thromboembolic disorders. - Smoking: do not use in women over 35 who smoke. - Cardiovascular risk: assess blood pressure and lipid profile regularly. - Liver disease: use with caution in patients with hepatic impairment. - Pregnancy and lactation: discontinue if pregnancy is confirmed; consult before breastfeeding. - Store at ambient temperature: keep below 25°C in the original packaging, protected from moisture and light.
What does Dienogest, Ethinylestradiol interact with?
Jeanine may interact with other medicines, altering its effectiveness or safety.
Major Interactions (Avoid): - Anticoagulants: may reduce efficacy of hormonal contraception. - Certain antiepileptics (e.g., carbamazepine, phenytoin): increase metabolism, lowering contraceptive effect.
Moderate Interactions (Monitor Closely): - Antibiotics (e.g., rifampicin): may modestly decrease hormone levels. - Herbal supplements (e.g., St. John’s wort): can reduce contraceptive reliability. - Antiretrovirals (e.g., protease inhibitors): may affect hormone concentrations.



