Jeanine (Dienogest, Ethinylestradiol)

Dienogest/Ethinylestradiol, the active ingredients in Jeanine, are a combined oral contraceptive presented as a tablet for oral use. It is indicated for contraception and for regulation of menstrual cycles in women of reproductive age.

GNH USA supplies Jeanine as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Jeanine, a combined hormonal contraceptive, acts on the reproductive endocrine system to prevent pregnancy and to normalize menstrual bleeding.

Contraception: prevents unintended pregnancy by inhibiting ovulation and altering cervical mucus. Regulation of menstrual cycles: reduces irregular bleeding and dysmenorrhea by stabilising the endometrial lining.

Jeanine may cause a range of adverse reactions. The most frequently reported events are generally mild and transient.

Common Side Effects: - Nausea: mild to moderate stomach upset. - Breast tenderness: discomfort or swelling of the breasts. - Headache: occasional tension‑type headache. - Spotting or breakthrough bleeding: irregular light bleeding between periods.

Serious or Rare Side Effects: - Venous thromboembolism: blood clots in deep veins or lungs. - Arterial thrombosis: clot formation in arteries leading to stroke or myocardial infarction. - Severe hypertension: sudden increase in blood pressure. - Allergic reactions: rash, swelling, or anaphylaxis. - Liver dysfunction: abnormal liver enzymes or jaundice. - Visual disturbances: sudden loss of vision or eye pain.

Before prescribing Jeanine, clinicians should evaluate individual risk factors and counsel patients on safe use. - Assess cardiovascular risk: review history of thrombosis, smoking, and hypertension. - Avoid smoking: especially in women over 35 years of age. - Review liver function: monitor hepatic enzymes in patients with liver disease. - Consider drug interactions: check concomitant medications that may affect hormone levels. - Store at ambient temperature: keep in the original pack, protect from moisture and light.

Jeanine can interact with several medicines that alter hormone metabolism or increase clotting risk.

Major Interactions (Avoid): - Enzyme‑inducing anticonvulsants (e.g., carbamazepine): may reduce contraceptive efficacy. - Potent CYP3A4 inhibitors (e.g., ketoconazole): may increase hormone concentrations. - Hormonal breast‑cancer therapies (e.g., tamoxifen): may be contraindicated.

Moderate Interactions (Monitor Closely): - Rifampin and other strong antibiotics: may lower effectiveness. - St. John’s wort herbal supplement: may decrease plasma hormone levels.