Jaydess

Levonorgestrel, the active ingredient in Jaydess, is a progestin presented as a 13.5 mg intrauterine system (IUS) for intrauterine use. It prevents pregnancy by providing continuous local hormone release.

GNH USA supplies Jaydess as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Levonorgestrel delivered via the intrauterine system is used in the contraceptive pathway to prevent unintended pregnancy.

- Contraception (prevention of pregnancy): provides highly effective long‑term birth control.

Levonorgestrel IUS may cause a range of adverse reactions.

Common Side Effects: - Irregular bleeding or spotting - Amenorrhea (absence of periods) - Pelvic or lower abdominal pain - Cramping during or after insertion - Vaginal discharge - Headache

Serious or Rare Side Effects: - Uterine perforation during insertion - Device expulsion or displacement - Pelvic infection (e.g., PID) - Ectopic pregnancy if contraception fails - Severe allergic reaction (rash, swelling) - Hormonal effects such as severe migraine or depression

Before insertion and during use, certain precautions should be observed.

- Confirm non‑pregnancy: ensure patient is not pregnant prior to placement. - Evaluate uterine anatomy: rule out fibroids, septum, or other abnormalities. - Screen for infection: postpone insertion if active pelvic infection is present. - Assess hypersensitivity: avoid in patients with known allergy to levonorgestrel. - Store at room temperature: keep in original packaging, protect from moisture and direct sunlight.

Levonorgestrel IUS has limited systemic exposure, but some drug interactions may affect efficacy.

Major Interactions (Avoid): - Rifampicin, carbamazepine, phenytoin: enzyme inducers that may lower levonorgestrel levels. - Ketoconazole, itraconazole: strong antifungal agents that may increase levonorgestrel exposure.

Moderate Interactions (Monitor Closely): - Certain antibiotics (e.g., tetracycline): may slightly reduce contraceptive effectiveness. - Antiretrovirals such as efavirenz: possible reduction in hormone levels. - Herbal supplements like St. John's wort: may lower efficacy. - Hormonal therapies (combined oral contraceptives): monitor for additive hormonal effects.