Jaydess

Levonorgestrel, the active ingredient in Jaydess, is a progestin presented as a 20 µg/day intrauterine system for intrauterine use. It prevents pregnancy and can be used to manage heavy menstrual bleeding.

GNH USA supplies Jaydess as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Jaydess is a hormonal intrauterine system that acts on the reproductive endocrine pathway to provide contraception and control menstrual bleeding. - Contraception: offers highly effective, reversible birth control for women of reproductive age. - Heavy menstrual bleeding: reduces menstrual blood loss and improves quality of life. - Menstrual cycle regulation: helps achieve more predictable bleeding patterns and may lessen dysmenorrhea.

Jaydess may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects: - Irregular bleeding or spotting. - Amenorrhea (absence of periods). - Pelvic or abdominal cramping. - Hormonal acne.

Serious or Rare Side Effects: - Uterine perforation during insertion. - Expulsion of the intrauterine system. - Pelvic infection (e.g., PID). - Ectopic pregnancy if contraception fails. - Allergic reaction to device components.

Before insertion and during use, certain precautions should be observed to ensure safety. - Pregnancy screening: confirm the patient is not pregnant prior to insertion. - Contraindications: avoid use in active pelvic infection, unexplained vaginal bleeding, or known hypersensitivity to levonorgestrel. - Position verification: check IUS placement with ultrasound after insertion. - Device removal: ensure removal before the approved duration expires. - Store at ambient temperature: keep in original packaging, protect from moisture and direct sunlight.

Levonorgestrel released from Jaydess can be affected by other medicines that alter hormone metabolism.

Major Interactions (Avoid): - Rifampin and other strong enzyme inducers: may reduce levonorgestrel efficacy. - Carbamazepine: can lower systemic hormone levels. - Efavirenz (antiretroviral): may compromise contraceptive effectiveness.

Moderate Interactions (Monitor Closely): - Ketoconazole and other azole antifungals: may increase hormone exposure. - St. John’s wort: moderate enzyme induction may reduce effectiveness. - Certain antibiotics (e.g., griseofulvin): may modestly affect hormone levels.