GNH USA

Europe — EMA

Jansitin Duo

GNH USA supplies Jansitin Duo (Metformin/Sitagliptin), a biguanide and DPP‑4 inhibitor for type 2 diabetes mellitus. Request a quote for global supply.

Metformin Hydrochloride, Sitagliptin

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What is Metformin Hydrochloride, Sitagliptin?

Metformin Hydrochloride and Sitagliptin, the active ingredients in Jansitin Duo, are a biguanide and DPP‑4 inhibitor presented as a tablet for oral use. It treats type 2 diabetes mellitus in adult patients by improving glycaemic control. GNH USA supplies Jansitin Duo as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Metformin Hydrochloride, Sitagliptin used for?

Jansitin Duo combines metformin and sitagliptin to improve glucose regulation in type 2 diabetes mellitus.

Type 2 diabetes mellitus: lowers fasting and post‑prandial blood glucose levels to achieve target HbA1c. Inadequate control on monotherapy: adds complementary mechanisms to reach glycaemic goals. Adjunct to diet and exercise: supports lifestyle measures in patients who need additional pharmacologic therapy.

What are the side effects of Metformin Hydrochloride, Sitagliptin?

Jansitin Duo may cause a range of adverse reactions.

Common Side Effects: - Nausea or upset stomach - Diarrhoea - Abdominal discomfort - Headache - Upper respiratory tract infection - Mild hypoglycaemia (when combined with sulfonylureas or insulin)

Serious or Rare Side Effects: - Lactic acidosis - Acute pancreatitis - Severe hypoglycaemia - Allergic reactions (rash, angio‑edema) - Hepatic dysfunction - Renal impairment worsening

What precautions apply to Metformin Hydrochloride, Sitagliptin?

Before prescribing Jansitin Duo, clinicians should consider several safety aspects.

Renal function: assess eGFR and avoid use in severe renal impairment. Hepatic impairment: use with caution and monitor liver enzymes. Risk of lactic acidosis: contraindicated in conditions predisposing to hypoxia. Pregnancy and lactation: safety not established; avoid unless benefits outweigh risks. Drug interactions: review concomitant medications that may affect metformin or sitagliptin levels. Store at ambient temperature: keep in the original pack, protect from moisture.

What does Metformin Hydrochloride, Sitagliptin interact with?

Jansitin Duo can interact with several medicines, requiring careful management.

Major Interactions (Avoid): - Iodinated contrast agents: may precipitate renal dysfunction. - Cimetidine: increases sitagliptin plasma concentrations. - Insulin or sulfonylureas: heightened risk of hypoglycaemia.

Moderate Interactions (Monitor Closely): - Diuretics: may affect renal clearance of metformin. - ACE inhibitors or ARBs: monitor renal function and potassium. - Beta‑blockers: may mask hypoglycaemia symptoms.

Frequently asked questions

What is Jansitin Duo used for?+
Jansitin Duo is indicated for the treatment of type 2 diabetes mellitus in adults. It combines metformin, a biguanide that improves insulin sensitivity, with sitagliptin, a DPP‑4 inhibitor that enhances incretin activity, providing complementary glucose‑lowering effects when diet, exercise, or single‑agent therapy are insufficient.
How does Metformin Hydrochloride and Sitagliptin work in Jansitin Duo?+
Metformin Hydrochloride reduces hepatic glucose production and increases peripheral insulin sensitivity, while Sitagliptin blocks the DPP‑4 enzyme, raising levels of incretin hormones that stimulate insulin release and suppress glucagon. Together, they lower fasting and post‑prandial blood glucose, helping patients achieve target glycaemic control.
What is the usual dose of Jansitin Duo?+
The dosage of Jansitin Duo is individualized by the prescribing clinician based on the patient’s renal function, glycaemic targets, and concomitant therapies. Physicians typically start with a low dose and titrate as needed, following local prescribing guidelines and monitoring blood glucose and safety parameters.
Is Jansitin Duo safe in pregnancy or breastfeeding?+
Safety of Jansitin Duo in pregnancy and lactation has not been established. Current guidance advises avoiding its use unless the potential benefit justifies the possible risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternative treatment options with their healthcare provider.
How do I order Jansitin Duo from GNH USA?+
To order Jansitin Duo, submit an enquiry on the product page at gnh-usa.com with the required quantity. GNH USA works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any required temperature control), and assistance with import documentation.
How does Jansitin Duo compare with other antidiabetic options?+
Compared with metformin or sitagliptin monotherapy, Jansitin Duo offers dual mechanisms in a single tablet, potentially improving adherence and providing greater HbA1c reduction. It is generally more effective than either component alone but may carry a higher risk of combined side‑effects, requiring careful patient selection and monitoring.
How should Jansitin Duo be stored and handled?+
Store Jansitin Duo at ambient temperature, below 25 °C, in the original packaging to protect it from moisture and light. Keep the tablet container tightly closed and out of reach of children. Do not store in a refrigerator or freezer unless specifically instructed by the supplier.
How is Jansitin Duo administered?+
Jansitin Duo is taken orally as a whole tablet, usually with meals to reduce gastrointestinal discomfort. The tablet should be swallowed with a full glass of water and not crushed or chewed, unless a prescriber advises otherwise.
What are the most serious risks to watch for while taking Jansitin Duo?+
The most serious risks include lactic acidosis (especially in patients with renal impairment), acute pancreatitis, severe hypoglycaemia when combined with insulin or sulfonylureas, and rare allergic reactions such as rash or angio‑edema. Patients should be instructed to seek immediate medical attention if they experience unexplained abdominal pain, rapid breathing, or signs of an allergic reaction.
Who should not use Jansitin Duo?+
Jansitin Duo is contraindicated in patients with severe renal impairment (eGFR < 30 mL/min/1.73 m²), known hypersensitivity to metformin, sitagliptin, or any excipients, and in those with a history of lactic acidosis. Caution is also advised for individuals with significant hepatic disease, heart failure, or uncontrolled heart rhythm disorders.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Metformin Hydrochloride, Sitagliptin
Route
Oral Use
Manufacturer
G.L. Pharma Gmbh
Origin
EU

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