Izifet

Levothyroxine Sodium, the active ingredient in Izifet, is a thyroid hormone presented as an oral tablet for systemic use. It replaces deficient endogenous thyroid hormone and is used to treat hypothyroidism, thyroid hormone replacement therapy, and goiter in adults and children.

GNH USA supplies Izifet as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies, clinics and procurement teams worldwide, ensuring quality and regulatory compliance across markets. Our distribution network adheres to stringent quality standards and supports timely delivery to healthcare providers.

Levothyroxine Sodium is used to restore normal thyroid hormone levels in conditions affecting the thyroid gland.

- Hypothyroidism: restores deficient thyroid hormone, normalizing metabolism and alleviating symptoms such as fatigue and weight gain. - Thyroid hormone replacement therapy after thyroidectomy or radioactive iodine: provides the necessary hormone to maintain metabolic homeostasis. - Goiter associated with thyroid hormone deficiency: reduces gland enlargement by correcting hormonal imbalance.

Levothyroxine Sodium may cause a range of adverse reactions, which are grouped by frequency and severity.

Common Side Effects: - Headache - Insomnia - Palpitations - Weight loss - Heat intolerance - Tremor

Serious or Rare Side Effects: - Allergic reaction (rash, angioedema) - Chest pain or arrhythmia - Severe hyperthyroidism symptoms - Bone loss (osteoporosis) with long‑term overtreatment

When prescribing Levothyroxine Sodium, clinicians should consider several safety measures.

- Monitor thyroid function tests regularly: adjust dose based on TSH and free T4 levels. - Initiate therapy with low dose in elderly patients: reduce risk of cardiac stress. - Avoid use in untreated adrenal insufficiency: may precipitate adrenal crisis. - Caution during pregnancy and breastfeeding: weigh benefits against potential fetal thyroid effects. - Store at ambient temperature: keep in original container, protect from moisture and light.

Levothyroxine Sodium can interact with various medicines that affect its absorption or metabolism.

Major Interactions (Avoid): - Antacids containing aluminum or magnesium: decrease levothyroxine absorption. - Calcium supplements or calcium carbonate: bind levothyroxine and reduce bioavailability. - Iron salts (ferrous sulfate): impair absorption when taken concurrently. - Cholesterol‑lowering resins (e.g., cholestyramine): sequester levothyroxine. - Amiodarone: alters thyroid hormone metabolism and may require dose adjustment.

Moderate Interactions (Monitor Closely): - Warfarin: levothyroxine may enhance anticoagulant effect, monitor INR. - Corticosteroids: may increase levothyroxine clearance, watch thyroid levels. - Estrogen therapy (including oral contraceptives): may raise levothyroxine requirement.