GNH USA

Europe — EMA

Ixprim Effervescent (Tramadol Hydrochloride, Paracetamol)

GNH USA supplies Ixprim Effervescent (Tramadol Hydrochloride / Paracetamol), an analgesic for acute, post‑operative and traumatic pain. Request a quote.

Tramadol Hydrochloride, Paracetamol

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What is Tramadol Hydrochloride, Paracetamol?

Tramadol Hydrochloride, the active ingredient in Ixprim Effervescent, is an opioid analgesic presented as an effervescent tablet for oral use. Combined with paracetamol, it provides analgesic and antipyretic effects for the management of moderate to severe acute pain, including post‑operative and traumatic pain, in adult patients.

GNH USA supplies Ixprim Effervescent as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Tramadol Hydrochloride, Paracetamol used for?

Ixprim Effervescent, containing tramadol and paracetamol, is indicated for pain conditions where combined opioid and non‑opioid analgesia is required.

- Moderate to severe acute pain: provides rapid relief of pain intensity. - Post‑operative pain: reduces pain after surgical procedures. - Traumatic pain: alleviates pain resulting from injuries.

What are the side effects of Tramadol Hydrochloride, Paracetamol?

Common Side Effects: - Nausea: mild to moderate feeling of sickness. - Dizziness: transient light‑headedness. - Constipation: reduced bowel movements. - Headache: mild to moderate pain in the head. - Dry mouth: reduced salivation. - Sweating: increased perspiration.

Serious or Rare Side Effects: - Seizures: risk increased at high doses or with interacting drugs. - Respiratory depression: slowed breathing, especially in opioid‑naïve patients. - Allergic reactions: rash, urticaria, or anaphylaxis. - Serotonin syndrome: agitation, hyperthermia, and neuromuscular abnormalities. - Hepatic injury: elevated liver enzymes or jaundice. - Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.

What precautions apply to Tramadol Hydrochloride, Paracetamol?

Before prescribing Ixprim Effervescent, consider the following precautions: - Assess pain severity: ensure opioid therapy is justified for the level of pain. - Review respiratory history: avoid in patients with severe asthma or chronic obstructive pulmonary disease. - Monitor for dependence: limit duration and assess for signs of misuse. - Avoid concomitant MAO inhibitors: discontinue MAO inhibitors at least 14 days before use. - Adjust in hepatic impairment: consider dose reduction or alternative therapy. - Store at ambient temperature: keep in the original pack, protect from moisture.

What does Tramadol Hydrochloride, Paracetamol interact with?

Ixprim Effervescent may interact with several medicines. Review patient medication lists carefully.

Major Interactions (Avoid): - MAO inhibitors: risk of serotonin syndrome. - CNS depressants (benzodiazepines, alcohol): enhanced respiratory depression. - SSRIs or SNRIs: increased risk of serotonin syndrome. - CYP2D6 inhibitors (e.g., quinidine, fluoxetine): elevated tramadol plasma levels. - Warfarin: possible increased bleeding tendency.

Moderate Interactions (Monitor Closely): - Anticonvulsants (carbamazepine, phenytoin): may reduce analgesic efficacy. - Diuretics: may potentiate hypotensive effects of paracetamol. - Rifampicin: may lower plasma concentrations of both components.

Frequently asked questions

What is Ixprim Effervescent used for?+
Ixprim Effervescent is a prescription medication that combines tramadol hydrochloride and paracetamol to provide analgesic and antipyretic effects. It is used to treat moderate to severe acute pain, including pain after surgery and pain resulting from injuries.
How does tramadol hydrochloride work in Ixprim Effervescent?+
Tramadol acts as a µ‑opioid receptor agonist and inhibits the reuptake of norepinephrine and serotonin, which enhances descending pain‑inhibitory pathways in the central nervous system. This opioid activity, together with paracetamol’s central COX inhibition, produces synergistic pain relief.
What is the usual dose of Ixprim Effervescent?+
The specific dose and dosing schedule of Ixprim Effervescent are determined by the prescribing clinician based on the patient’s pain severity, medical history, and response to therapy. Patients should follow the prescriber’s instructions and not adjust the dose on their own.
Is Ixprim Effervescent safe during pregnancy or breastfeeding?+
Safety of Ixprim Effervescent in pregnancy or while breastfeeding has not been definitively established. Healthcare providers should weigh the potential benefits against possible risks and consider alternative therapies when treating pregnant or nursing patients.
How do I order Ixprim Effervescent from GNH USA?+
To order Ixprim Effervescent, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.
How does Ixprim Effervescent compare with other pain medications?+
Ixprim combines an opioid (tramadol) with a non‑opioid analgesic (paracetamol), offering a broader spectrum of pain control than either component alone. Compared with single‑agent opioids, it may achieve effective analgesia at lower opioid doses, potentially reducing opioid‑related side effects.
What are the storage requirements for Ixprim Effervescent?+
Ixprim Effervescent should be stored at ambient temperature, below 25 °C, in its original packaging. Protect the tablets from moisture and keep them out of reach of children.
How is Ixprim Effervescent administered?+
The medication is supplied as an effervescent tablet that is dissolved in a specified amount of water before oral ingestion. Patients should follow the instructions on the package insert and the prescriber’s guidance for proper preparation and consumption.
What are the most serious risks associated with Ixprim Effervescent?+
Serious risks include respiratory depression, especially in opioid‑naïve individuals or when combined with other depressants, seizures at high doses or with interacting drugs, and rare but severe allergic reactions such as anaphylaxis or Stevens‑Johnson syndrome.
Who should not use Ixprim Effervescent?+
Ixprim Effervescent is contraindicated in patients with known hypersensitivity to tramadol, paracetamol, or any excipients, in those taking monoamine oxidase inhibitors, and in individuals with severe respiratory insufficiency or uncontrolled epilepsy.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Tramadol Hydrochloride, Paracetamol
Route
Oral Use
Manufacturer
Grünenthal Pharma Ltd.
Origin
EU

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