GNH USA

Europe — EMA

Ivabradina Generis (Ivabradine Hydrochloride)

GNH USA supplies Ivabradina Generis (Ivabradine), an If channel inhibitor for stable angina and heart failure with reduced ejection fraction. Request a quote.

Ivabradine Hydrochloride

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1
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What is Ivabradine Hydrochloride?

Ivabradine, the active ingredient in Ivabradina Generis, is an If channel inhibitor presented as a tablet for oral use. It reduces heart rate in patients with chronic stable angina and heart failure with reduced ejection fraction. GNH USA supplies Ivabradina Generis as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Ivabradine Hydrochloride used for?

Ivabradina Generis acts on the cardiac If current to control heart rate in specific cardiovascular conditions. - Chronic stable angina pectoris: improves exercise tolerance and reduces the frequency of angina attacks. - Heart failure with reduced ejection fraction (NYHA II–III): lowers heart rate, helping to alleviate symptoms and improve functional capacity. - Coronary artery disease (as adjunct therapy): assists in heart‑rate control when beta‑blockers are unsuitable.

What are the side effects of Ivabradine Hydrochloride?

Adverse reactions may occur with ivabradine therapy.

Common Side Effects: - Bradycardia: excessively low heart rate. - Visual disturbances (phosphenes): transient luminous phenomena. - Headache. - Dizziness. - Fatigue. - Nausea.

Serious or Rare Side Effects: - Symptomatic atrial fibrillation. - Severe hypotension. - Syncope (fainting).

What precautions apply to Ivabradine Hydrochloride?

Ivabradina Generis requires careful patient assessment and monitoring. - Cardiovascular assessment: evaluate baseline heart rate and rhythm before initiation. - Concomitant beta‑blocker use: avoid excessive heart‑rate reduction. - Liver impairment: dose adjustment may be needed. - Pregnancy and lactation: safety not established; use only if benefits outweigh risks. - Store at ambient temperature: keep below 25°C in the original container, protect from moisture and light.

What does Ivabradine Hydrochloride interact with?

Ivabradine may interact with several medicines, altering its efficacy or safety.

Major Interactions (Avoid): - Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): increase ivabradine plasma levels. - Strong CYP3A4 inducers (e.g., rifampicin, carbamazepine): reduce ivabradine exposure. - Concomitant use with other bradycardic agents (e.g., digoxin, diltiazem): risk of severe bradycardia.

Moderate Interactions (Monitor Closely): - Moderate CYP3A4 inhibitors (e.g., fluconazole): may modestly raise ivabradine concentrations. - Verapamil: can enhance bradycardic effect. - Antihypertensives: monitor blood pressure and heart rate.

Frequently asked questions

What conditions is Ivabradina Generis used to treat?+
Ivabradina Generis is prescribed for chronic stable angina pectoris and for heart failure with reduced ejection fraction (NYHA class II–III). In both cases the drug helps control heart rate, reducing angina episodes and improving symptoms associated with heart failure.
How does ivabradine work to lower heart rate?+
Ivabradine selectively blocks the funny (If) current in the sino‑atrial node, which is responsible for spontaneous pacemaker activity. By inhibiting this current, the drug slows the rate of depolarisation, leading to a lower heart rate without affecting the strength of cardiac contraction.
What is the usual dose of Ivabradina Generis?+
The dose of Ivabradina Generis is determined individually by the prescribing clinician based on the patient’s heart‑rate, clinical condition, and any concomitant therapies. The prescriber will set the appropriate strength and dosing schedule.
Is Ivabradina Generis safe during pregnancy or breastfeeding?+
Safety of ivabradine in pregnancy and lactation has not been established. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.
How do I order Ivabradina Generis from GNH USA?+
To order, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.
How does ivabradine compare with beta‑blockers?+
Both ivabradine and beta‑blockers lower heart rate, but ivabradine does so by selectively inhibiting the If current without affecting contractility or blood pressure. Beta‑blockers act on adrenergic receptors and have broader cardiovascular effects, which may be contraindicated or less tolerated in some patients.
What are the recommended storage conditions for Ivabradina Generis?+
Store Ivabradina Generis at ambient temperature, preferably below 25 °C. Keep the tablets in the original packaging, protect them from moisture and direct sunlight, and ensure the container is tightly closed to maintain product stability.
How is Ivabradina Generis administered?+
Ivabradina Generis is taken orally, usually with a glass of water. The exact timing (e.g., with or without food) and frequency are determined by the prescribing clinician based on the individual treatment plan.
What are the most serious risks associated with ivabradine?+
The most serious risks include symptomatic bradycardia, atrial fibrillation, severe hypotension, and syncope. Patients should be monitored for signs of excessively low heart rate or arrhythmias, and therapy should be adjusted or discontinued if these events occur.
Who should not use Ivabradina Generis?+
Ivabradina Generis should be avoided in patients with severe hepatic impairment, uncontrolled hypotension, acute decompensated heart failure, or those taking strong CYP3A4 inhibitors or other bradycardic agents that could cause excessive heart‑rate reduction.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Ivabradine Hydrochloride
Route
Oral Use
Manufacturer
Generis Farmacêutica, S.A.
Origin
EU

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