GNH USA

Europe — EMA

Ivabradin Ratiopharm (Ivabradine)

GNH USA supplies Ivabradin Ratiopharm (Ivabradine), an If channel inhibitor for angina and heart failure with reduced ejection fraction. Request a quote.

Ivabradine

Request sourcing

1
Pack/s

What is Ivabradine?

Ivabradine, the active ingredient in Ivabradin Ratiopharm, is an If channel inhibitor presented as an oral tablet for oral use. It lowers heart rate and is used in chronic stable angina pectoris and heart failure with reduced ejection fraction in adult patients.

GNH USA supplies Ivabradin Ratiopharm as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Ivabradine used for?

Ivabradine is indicated for cardiovascular conditions where heart‑rate reduction is beneficial.

Chronic stable angina pectoris: reduces the frequency of angina attacks by lowering heart rate. Heart failure with reduced ejection fraction: improves symptoms and reduces hospitalisation by decreasing heart rate. Elevated resting heart rate: helps achieve target heart rate when beta‑blockers are unsuitable.

What are the side effects of Ivabradine?

Ivabradine may cause a range of adverse reactions, which are categorised by frequency and severity.

Common Side Effects: - Visual disturbances (phosphenes): transient luminous phenomena. - Bradycardia: heart rate below prescribed target. - Headache. - Dizziness.

Serious or Rare Side Effects: - Symptomatic bradycardia leading to syncope. - Atrial fibrillation. - Severe hypotension or heart block.

What precautions apply to Ivabradine?

When prescribing Ivabradine, clinicians should consider several safety precautions. - Cardiovascular assessment: evaluate baseline heart rate and rhythm before initiation. - Monitoring: check heart rate regularly after starting therapy and after dose adjustments. - Contraindications: avoid use in patients with severe hepatic impairment. - Concomitant medications: use caution with other heart‑rate lowering agents (e.g., beta‑blockers, calcium channel blockers). - Pregnancy and lactation: safety not established; weigh risks and benefits. - Store at ambient temperature below 25°C: keep in the original pack, protect from moisture.

What does Ivabradine interact with?

Ivabradine interacts with several medicines that can alter its plasma concentration or additive heart‑rate effects.

Major Interactions (Avoid): - Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin, itraconazole): may increase ivabradine levels and cause excessive bradycardia. - Other heart‑rate lowering agents (beta‑blockers, diltiazem, verapamil, digoxin): risk of severe bradycardia. - Concomitant use with other If channel inhibitors: additive effect on sinoatrial node.

Moderate Interactions (Monitor Closely): - Moderate CYP3A4 inhibitors (e.g., fluconazole, erythromycin): may require dose adjustment. - Diuretics causing electrolyte imbalance: can predispose to arrhythmias. - Antihypertensive agents (ACE inhibitors, ARBs): monitor blood pressure and heart rate.

Frequently asked questions

What is Ivabradin Ratiopharm used for?+
Ivabradin Ratiopharm contains ivabradine, which is prescribed to lower heart rate in adults with chronic stable angina pectoris and in patients with heart failure with reduced ejection fraction. By reducing the heart rate, it helps relieve angina symptoms and improves functional capacity in heart‑failure patients.
How does ivabradine work?+
Ivabradine works by selectively blocking the funny (If) current in the sinoatrial node. This current controls the pacemaker activity that sets the heart’s rhythm. Inhibition slows the spontaneous depolarisation of the node, leading to a lower heart rate while leaving contractility and blood pressure largely unchanged.
What is the usual dose of Ivabradin Ratiopharm?+
The appropriate dose of Ivabradin Ratiopharm is determined by the prescribing clinician based on the individual’s clinical condition, baseline heart rate, and response to therapy. Dosage adjustments are made according to therapeutic goals and tolerability, and patients should follow the prescriber’s instructions precisely.
Is Ivabradin Ratiopharm safe in pregnancy or breastfeeding?+
Safety data for ivabradine during pregnancy and lactation are limited. The drug should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant. Healthcare providers usually advise avoiding use unless absolutely necessary and may consider alternative therapies.
How do I order Ivabradin Ratiopharm from GNH USA?+
To place an order, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity of Ivabradin Ratiopharm. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.
How does Ivabradin Ratiopharm compare with the main alternative drug class?+
The primary alternative for heart‑rate reduction is the beta‑blocker class. Unlike beta‑blockers, ivabradine lowers heart rate without affecting beta‑adrenergic receptors, so it does not influence blood pressure or cause bronchospasm. This makes it useful when beta‑blockers are contraindicated or not tolerated, though beta‑blockers also provide additional anti‑ischemic benefits.
How should Ivabradin Ratiopharm be stored and handled?+
Ivabradin Ratiopharm should be stored at ambient temperature below 25 °C. Keep the tablets in the original packaging, protect them from moisture and direct sunlight, and keep them out of reach of children. No refrigeration is required.
How is Ivabradin Ratiopharm given or administered?+
The medication is taken orally, usually with or without food, as directed by the prescriber. Tablets should be swallowed whole with a glass of water. Patients are advised to take the dose at the same times each day to maintain consistent blood levels.
What are the most serious risks to watch for while taking Ivabradin Ratiopharm?+
Serious risks include symptomatic bradycardia that can lead to dizziness or fainting, atrial fibrillation, and severe hypotension or heart block. Patients should report any episodes of fainting, palpitations, or unusually slow heartbeats to their healthcare provider promptly.
Who should not use Ivabradin Ratiopharm?+
Ivabradin Ratiopharm is contraindicated in patients with severe hepatic impairment, those with a resting heart rate below 50 beats per minute, and individuals with sick sinus syndrome or second‑ or third‑degree atrioventricular block unless they have a permanent pacemaker. It should also be avoided in patients taking strong CYP3A4 inhibitors without dose adjustment.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
Send a sourcing enquiry for this product →

Product details

Drug
Ivabradine
Route
Oral Use
Manufacturer
Ratiopharm Gmbh
Origin
EU

Related products

Ivabradine 5 mg/1

Ivabradine 5 mg/1

Ivabradine · 5 mg

Ivabradine
TABLET, FILM COATED
Camber Pharmaceuticals, Inc.
USA
Ivabradine 7.5 mg/1

Ivabradine 7.5 mg/1

Ivabradine · 7.5 mg

Ivabradine
TABLET, FILM COATED
Camber Pharmaceuticals, Inc.
USA
Bivelen

Bivelen

Ivabradine

Delorbis Pharmaceuticals Limited
EU
Bixebra

Bixebra

Ivabradine

Krka-Farma D.O.O.
EU