Itraconazole Teva

Itraconazole, the active ingredient in Itraconazole Teva, is an azole antifungal presented as an oral formulation for oral use. It treats a range of fungal infections in adults and children when prescribed by a qualified health professional.

GNH USA supplies Itraconazole Teva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Itraconazole is used to treat fungal infections that affect the skin, lungs and other organs. - Dermatophyte infections: eradicates superficial fungal skin infections such as tinea corporis and tinea pedis. - Histoplasmosis: clears systemic infection caused by Histoplasma capsulatum. - Blastomycosis: treats disseminated disease caused by Blastomyces dermatitidis. - Coccidioidomycosis: resolves infection from Coccidioides species. - Aspergillosis: manages invasive disease caused by Aspergillus species. - Cryptococcal infections: combats systemic infection by Cryptococcus neoformans.

Itraconazole may cause a range of adverse reactions, from mild to severe.

Common Side Effects: - Nausea: mild to moderate stomach upset. - Vomiting: occasional emesis. - Abdominal pain: discomfort in the upper abdomen. - Headache: transient cranial pain. - Rash: skin redness or itching. - Taste disturbances: altered or reduced taste perception.

Serious or Rare Side Effects: - Hepatotoxicity: elevated liver enzymes or hepatitis. - Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis. - Cardiac failure: worsening of pre‑existing heart conditions. - QT interval prolongation: risk of arrhythmias. - Severe liver injury: hepatic failure requiring medical intervention.

Before initiating therapy, clinicians should assess patient risk factors and monitor for complications. - Liver function monitoring: obtain baseline and periodic liver enzyme tests. - Avoid hepatotoxic drugs: do not co‑administer with other agents known to affect liver health. - Caution in heart failure: assess cardiac status before use. - Dose adjustment in hepatic impairment: reduce dose as recommended for reduced liver function. - Grapefruit juice avoidance: advise patients not to consume grapefruit products. - Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Itraconazole interacts with several medicines; some combinations should be avoided while others require close observation.

Major Interactions (Avoid): - Rifampin: induces metabolism, markedly reducing itraconazole levels. - Ketoconazole: competitive inhibition leading to increased toxicity. - St. John’s wort: strong enzyme inducer decreasing efficacy. - Erythromycin: may increase itraconazole concentrations, raising toxicity risk. - HIV protease inhibitors (e.g., ritonavir): can cause unpredictable plasma levels.

Moderate Interactions (Monitor Closely): - Warfarin: potentiates anticoagulant effect, monitor INR. - Phenytoin: may lower itraconazole exposure, adjust dose if needed. - Carbamazepine: enzyme induction may reduce efficacy. - Digoxin: increased serum levels possible, watch for toxicity. - NSAIDs: may increase risk of gastrointestinal irritation.