GNH USA

Europe — EMA

Itraconazole Athlone Pharmaceuticals

GNH USA supplies Itraconazole (Itraconazole), an azole antifungal for infections such as dermatophytosis and onychomycosis. Request a quote for supply.

Itraconazole

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What is Itraconazole?

Itraconazole, the active ingredient in Itraconazole Athlone Pharmaceuticals, is an azole antifungal presented as an oral formulation for systemic use. It treats a variety of fungal infections in adults and children as prescribed by a healthcare professional.

GNH USA supplies Itraconazole Athlone Pharmaceuticals as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Itraconazole used for?

Itraconazole is an azole antifungal used to treat a range of systemic fungal infections.

- Dermatophytosis: effective for skin infections caused by dermatophyte fungi. - Onychomycosis: helps eradicate fungal infection of the nails. - Blastomycosis: used to manage infection by Blastomyces dermatitidis. - Histoplasmosis: treats disease caused by Histoplasma capsulatum. - Aspergillosis: employed in therapy of invasive Aspergillus infections. - Coccidioidomycosis: indicated for infection by Coccidioides species.

What are the side effects of Itraconazole?

Itraconazole may cause a variety of adverse reactions, ranging from mild to severe.

Common Side Effects: - Nausea: mild stomach upset. - Headache: transient discomfort. - Rash: skin irritation or redness.

Serious or Rare Side Effects: - Hepatotoxicity: elevated liver enzymes or liver injury. - Cardiac failure: rare cases of congestive heart failure. - Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.

What precautions apply to Itraconazole?

Before initiating therapy, consider the following precautions.

- Monitor liver function: baseline and periodic tests recommended. - Assess cardiac status: avoid in patients with existing heart failure. - Avoid grapefruit juice: may increase itraconazole plasma levels. - Check drug interactions: review all concomitant medications. - Pregnancy and lactation: use only if benefits outweigh potential risks. - Store at room temperature: keep in the original container, protect from moisture.

What does Itraconazole interact with?

Itraconazole has notable interactions that require attention.

Major Interactions (Avoid): - Rifampin: induces metabolism, markedly reducing itraconazole efficacy. - Ketoconazole: combined use increases risk of hepatotoxicity. - Carbamazepine: strong enzyme inducer that lowers itraconazole concentrations.

Moderate Interactions (Monitor Closely): - Cimetidine: may raise itraconazole levels, requiring dose adjustment. - Statins (e.g., simvastatin): increased risk of myopathy. - Oral contraceptives: potential reduction in contraceptive effectiveness.

Frequently asked questions

What is Itraconazole used for?+
Itraconazole is an azole antifungal prescribed to treat a range of systemic fungal infections, including skin and nail infections (dermatophytosis and onychomycosis), as well as deeper infections such as blastomycosis, histoplasmosis, aspergillosis, and coccidioidomycosis. The specific indication depends on the type and severity of the fungal disease diagnosed by a healthcare professional.
How does Itraconazole work?+
Itraconazole works by inhibiting the fungal enzyme lanosterol 14α‑demethylase, a key cytochrome P450 isoform involved in ergosterol synthesis. Blocking this step disrupts the formation of the fungal cell membrane, leading to increased membrane permeability and ultimately halting fungal growth and replication.
What determines the usual dose of Itraconazole?+
The appropriate dose of itraconazole is determined by the prescribing clinician based on the specific infection, its severity, patient weight, age, liver function, and any concomitant medications. Dosage regimens can vary widely, so patients should follow the exact instructions provided by their healthcare provider.
Is Itraconazole safe in pregnancy or breastfeeding?+
Safety data for itraconazole during pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss alternatives and risks with their doctor.
How do I order Itraconazole Athlone Pharmaceuticals from GNH USA?+
To order, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.
How does Itraconazole compare with the main alternative drug, Fluconazole?+
Both itraconazole and fluconazole belong to the azole class, but itraconazole has a broader spectrum against molds such as Aspergillus, whereas fluconazole is more active against Candida species. Itraconazole also has higher tissue penetration in skin and nails, making it preferred for onychomycosis, while fluconazole is often chosen for uncomplicated yeast infections.
What are the recommended storage conditions for Itraconazole?+
Itraconazole should be stored at room temperature, typically below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and avoid storing it in humid environments such as bathrooms.
How is Itraconazole administered?+
Itraconazole is administered orally, usually as tablets or capsules, and should be taken with food or a full glass of water to enhance absorption. The exact method of intake—such as whether to swallow whole or dissolve—depends on the specific product formulation and the prescriber's instructions.
What are the most serious risks associated with Itraconazole?+
The most serious risks include hepatotoxicity, which can manifest as elevated liver enzymes or liver injury, and rare cardiac complications such as congestive heart failure. Severe cutaneous reactions like Stevens‑Johnson syndrome may also occur. Patients should be monitored regularly for signs of liver dysfunction, heart problems, or skin changes.
Who should not use Itraconazole?+
Itraconazole is contraindicated in individuals with known hypersensitivity to itraconazole or any azole antifungal. Patients with uncontrolled heart failure, severe liver disease, or those taking certain contraindicated medications (e.g., strong CYP3A4 inducers like rifampin) should avoid using itraconazole unless a specialist determines it is safe.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Itraconazole
Route
Oral Use
Manufacturer
Athlone Pharmaceuticals Limited
Origin
EU

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