Itraconazol Stada

Itraconazole, the active ingredient in Itraconazol Stada, is a triazole antifungal presented as an oral formulation for systemic use. It treats a range of serious fungal infections in adults and children when prescribed by a qualified health professional.

GNH USA supplies Itraconazol Stada as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Itraconazole is a triazole antifungal that interferes with fungal cell membrane synthesis, making it effective against several systemic mycoses. - Invasive aspergillosis: treatment of life‑threatening lung infection caused by Aspergillus species. - Candidiasis (oropharyngeal and esophageal): eradication of Candida infections in the mouth and esophagus. - Dermatophytosis: clearance of skin infections caused by dermatophyte fungi. - Blastomycosis: resolution of infection caused by Blastomyces dermatitidis. - Histoplasmosis: management of disease due to Histoplasma capsulatum. - Sporotrichosis: therapy for infection by Sporothrix schenckii.

Common Side Effects: - Nausea: mild to moderate stomach upset. - Headache: transient cranial discomfort. - Rash: skin irritation or mild erythema. - Elevated liver enzymes: mild, often reversible increase.

Serious or Rare Side Effects: - Hepatotoxicity: severe liver injury requiring monitoring. - Stevens‑Johnson syndrome: rare but severe skin reaction. - Cardiac failure: worsening of pre‑existing heart conditions. - Visual disturbances: blurred vision or photophobia. - Severe allergic reactions: anaphylaxis or angioedema.

Itraconazole requires careful monitoring due to its potential impact on liver function and drug interactions. - Assess liver function: obtain baseline tests and repeat periodically. - Review concomitant medications: check for known interactions before prescribing. - Monitor cardiac status: use cautiously in patients with heart failure. - Avoid use in pregnancy: potential fetal risk, discuss alternatives. - Store at room temperature: keep in the original pack, protect from moisture and light.

Itraconazole interacts with many medicines that affect hepatic metabolism or share toxicity pathways. Major Interactions (Avoid): - Rifampin: markedly reduces itraconazole exposure. - Ketoconazole: additive hepatotoxic risk. - Erythromycin: increases itraconazole levels, risk of toxicity. - St. John’s wort: induces metabolism, lowering efficacy. - Other azole antifungals (e.g., voriconazole): may cause excessive plasma concentrations. Moderate Interactions (Monitor Closely): - Warfarin: may raise INR, require coagulation monitoring. - Simvastatin: increased risk of myopathy, consider dose adjustment. - Oral contraceptives: reduced effectiveness, advise backup contraception.