Itraconazol Dura

Itraconazole, the active ingredient in Itraconazol Dura, is an azole antifungal presented as an oral formulation for oral use. It treats systemic and localized fungal infections such as candidiasis, aspergillosis, dermatophyte infections and onychomycosis in adult patients.

GNH USA supplies Itraconazol Dura as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies, clinics and other healthcare facilities worldwide.

Itraconazole is an azole antifungal used to treat infections caused by susceptible fungi.

- Dermatophyte infections: effective in treating skin and nail infections caused by dermatophytes. - Onychomycosis: helps eradicate fungal infection of the nail plate. - Systemic candidiasis: used for invasive Candida infections. - Aspergillosis: indicated for treatment of aspergillosis in immunocompromised patients.

Common Side Effects: - Nausea - Vomiting - Abdominal pain - Headache

Serious or Rare Side Effects: - Hepatotoxicity, including severe liver injury - Congestive heart failure - Severe allergic reactions such as anaphylaxis

Precautions should be taken when prescribing itraconazole.

- Monitor liver function: obtain baseline liver tests and repeat periodically. - Assess cardiac status: avoid use in patients with existing heart failure. - Review concomitant medications: check for potential drug‑drug interactions. - Use caution in pregnancy: limited data, weigh risks against benefits. - Store at ambient temperature: keep in the original container, protect from moisture and light.

Itraconazole has several notable drug interactions.

Major Interactions (Avoid): - Strong CYP3A4 inhibitors (e.g., ketoconazole, ritonavir). - Certain statins metabolized by CYP3A4 (e.g., simvastatin). - Rifampin, a potent CYP3A4 inducer.

Moderate Interactions (Monitor Closely): - Warfarin: may increase anticoagulant effect. - Oral contraceptives: efficacy may be reduced.