GNH USA

Europe — EMA

Itokin

GNH USA supplies Itokin (Itopride Hydrochloride), a prokinetic for dyspepsia, gastroesophageal reflux disease and gastric motility disorders.

Itopride Hydrochloride

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What is Itopride Hydrochloride?

Itopride Hydrochloride, the active ingredient in Itokin, is a prokinetic presented as a oral formulation for oral use. It treats functional dyspepsia, gastroesophageal reflux disease and gastric motility disorders in adults. GNH USA supplies Itokin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Itopride Hydrochloride used for?

Itokin is a prokinetic agent that acts on gastrointestinal motility disorders. Functional dyspepsia: improves upper abdominal discomfort and early satiety by enhancing gastric emptying. Gastroesophageal reflux disease: reduces reflux episodes by promoting coordinated esophageal clearance. Gastric motility disorders: facilitates gastric emptying and intestinal transit, alleviating symptoms of delayed gastric emptying.

What are the side effects of Itopride Hydrochloride?

Adverse reactions may occur with Itokin use.

Common Side Effects: - Nausea - Diarrhea - Abdominal pain or discomfort - Headache - Dry mouth - Dizziness

Serious or Rare Side Effects: - Severe allergic reaction (anaphylaxis, rash, swelling) - Extrapyramidal symptoms (tremor, rigidity) - Cardiac arrhythmia - Hepatic injury or elevated liver enzymes - Persistent vomiting or severe dehydration

What precautions apply to Itopride Hydrochloride?

Before initiating therapy, consider the following precautions. Assess renal function: adjust use in patients with significant renal impairment. Monitor for allergic reactions: discontinue if signs of hypersensitivity appear. Use caution in cardiac disease: prokinetic activity may affect heart rate or rhythm. Avoid in known hypersensitivity to itopride or excipients. Pregnancy and breastfeeding: consult a physician before use. Store at room temperature: keep in the original pack, protect from moisture.

What does Itopride Hydrochloride interact with?

Itokin may interact with other medications; review patient medication lists.

Major Interactions (Avoid): - Anticholinergic agents: may diminish prokinetic efficacy. - Strong CYP3A4 inhibitors: could increase plasma concentrations of itopride.

Moderate Interactions (Monitor Closely): - Antacids: may reduce absorption if taken simultaneously. - Macrolide antibiotics: additive gastrointestinal effects possible. - Metoclopramide: combined dopaminergic antagonism may increase risk of extrapyramidal symptoms.

Frequently asked questions

What conditions is Itokin used to treat?+
Itokin contains itopride hydrochloride and is indicated for functional dyspepsia, gastroesophageal reflux disease, and other gastric motility disorders where enhanced gastrointestinal movement can relieve symptoms such as upper abdominal discomfort, early satiety, and reflux.
How does itopride hydrochloride work in the body?+
Itopride acts by blocking dopamine D2 receptors in the gut and inhibiting acetylcholinesterase. This dual action raises acetylcholine levels, stimulating smooth‑muscle contraction and promoting coordinated gastric emptying and intestinal transit.
What is the usual dose of Itokin?+
The dosage of Itokin is determined by the prescribing healthcare professional based on the individual’s condition, age, renal function and response to therapy. Patients should follow the prescriber’s instructions and not adjust the dose on their own.
Is Itokin safe to use during pregnancy or while breastfeeding?+
Safety data for itopride in pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their physician before starting Itokin.
How do I order Itokin from GNH USA?+
To request Itokin, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.
How does Itokin compare with other prokinetic agents?+
Itokin (itopride) differs from agents such as metoclopramide by combining dopamine D2 antagonism with acetylcholinesterase inhibition, which may result in a favorable side‑effect profile and effective gastric motility enhancement. Choice of therapy depends on clinical response, tolerability and physician judgment.
What are the recommended storage conditions for Itokin?+
Itokin should be stored at room temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and do not use it after the expiry date.
How is Itokin administered?+
Itokin is taken orally, usually with a glass of water. The tablet should be swallowed whole and not crushed or chewed unless otherwise directed by a healthcare professional. Timing relative to meals may be advised by the prescriber.
What are the most serious risks associated with Itokin?+
Serious adverse events, although rare, can include severe allergic reactions such as anaphylaxis, extrapyramidal symptoms like tremor or rigidity, cardiac arrhythmias, and significant liver injury. Patients should seek immediate medical attention if they experience any of these symptoms.
Who should not use Itokin?+
Itokin is contraindicated in individuals with known hypersensitivity to itopride hydrochloride or any of the tablet’s excipients. Caution is also advised for patients with severe cardiac disease, uncontrolled hepatic impairment, or those taking medications that may cause dangerous interactions.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Itopride Hydrochloride
Route
Oral Use
Manufacturer
Biofarm Sp. Z O.O.
Origin
EU

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