Itami Unidie

Diclofenac Sodium, the active ingredient in Itami Unidie, is a nonsteroidal anti‑inflammatory drug (NSAID) presented as a topical formulation for topical use. It provides pain relief and reduces inflammation in musculoskeletal conditions for adult patients. GNH USA supplies Itami Unidie as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Diclofenac Sodium is applied topically to manage inflammatory pain in the musculoskeletal system. - Osteoarthritis: reduces joint pain and improves function in affected joints. - Rheumatoid arthritis: alleviates localized joint inflammation and discomfort. - Sprains and strains: diminishes pain and swelling in soft‑tissue injuries. - Post‑operative pain: provides localized analgesia after minor surgical procedures.

Topical diclofenac is generally well tolerated, but adverse reactions can occur.

Common Side Effects: - Skin irritation at the application site: redness, itching, or burning sensation. - Dryness or peeling of the skin. - Mild rash or contact dermatitis. - Localized swelling. - Sensation of warmth or tingling.

Serious or Rare Side Effects: - Severe allergic reaction: hives, swelling of face or throat, difficulty breathing. - Stevens‑Johnson syndrome or toxic epidermal necrolysis. - Systemic NSAID effects: gastrointestinal ulceration or bleeding. - Liver enzyme elevation. - Kidney function impairment.

When using topical diclofenac, consider the following precautions. - Contraindications: avoid use in patients with known hypersensitivity to diclofenac or other NSAIDs. - Pregnancy: consult a healthcare professional before use; safety data are limited. - Breastfeeding: discuss potential risks with a physician. - Skin integrity: do not apply to broken, infected, or irritated skin. - Drug interactions: review concomitant medications for possible NSAID interactions. - Store at ambient temperature: keep in original packaging, protect from moisture and direct sunlight.

Diclofenac sodium may interact with other medicines, requiring careful management.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): increased risk of bleeding. - Other NSAIDs or COX‑2 inhibitors: heightened gastrointestinal toxicity. - Lithium: elevated lithium serum levels.

Moderate Interactions (Monitor Closely): - ACE inhibitors or ARBs: possible reduction in renal function. - Diuretics: potential for decreased renal perfusion. - Methotrexate: risk of increased methotrexate toxicity.