Isosorbide Mononitraat Retard Rph

Isosorbide mononitrate, the active ingredient in Isosorbide Mononitrate Retard Rph, is a nitrate presented as an oral extended‑release tablet for oral use. It is used to prevent angina pectoris and to treat chronic stable angina in adults. GNH USA supplies Isosorbide Mononitrate Retard Rph as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Isosorbide mononitrate is a nitrate that acts on the coronary circulation to relieve myocardial oxygen demand. Angina pectoris: reduces the frequency and severity of angina attacks. Chronic stable angina: improves exercise tolerance and reduces symptom burden. Ischemic heart disease: helps prevent angina episodes in patients with documented coronary artery disease.

Common Side Effects: - Headache: mild to moderate, often transient. - Dizziness or light‑headedness, especially on standing. - Flushing of the face or neck. - Nausea or mild gastrointestinal discomfort. - Palpitations or tachycardia.

Serious or Rare Side Effects: - Severe hypotension leading to syncope. - Allergic reactions such as rash, pruritus, or angioedema. - Rare cases of myocardial infarction or unstable angina. - Life‑threatening hypotensive crisis when combined with other vasodilators. - Hemorrhagic events in patients with coagulopathy.

Before initiating therapy, consider the following precautions: - Assess cardiovascular status: ensure stable hemodynamics. - Avoid concurrent use with phosphodiesterase‑5 inhibitors: risk of profound hypotension. - Monitor blood pressure regularly, especially after dose changes. - Adjust dose in hepatic impairment: reduced clearance may increase exposure. - Store at room temperature: keep in the original pack, protect from moisture and direct sunlight.

Isosorbide mononitrate may interact with several drug classes. Major Interactions (Avoid): - Other nitrates (e.g., nitroglycerin, isosorbide dinitrate): additive vasodilation. - Phosphodiesterase‑5 inhibitors (sildenafil, tadalafil): risk of severe hypotension. - Sodium nitrite: potentiates nitrate effect. Moderate Interactions (Monitor Closely): - Antihypertensives (ACE inhibitors, beta‑blockers, calcium channel blockers): may enhance blood pressure lowering. - Diuretics: can increase orthostatic hypotension. - Alcohol: may intensify vasodilatory effects.