Isosorbidedinitraat-Vaselinecrème 1% Fna Fagron Nl

Isosorbide dinitrate, the active ingredient in Isosorbidedinitraat-Vaselinecrème 1% Fna Fagron Nl, is a nitrate vasodilator presented as a 1% w/w Vaseline cream for rectal use. It treats and prevents angina pectoris and relieves sphincter spasm in patients with anal fissure.

GNH USA supplies Isosorbidedinitraat-Vaselinecrème 1% Fna Fagron Nl as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals and pharmacies worldwide.

Isosorbide dinitrate, a nitrate vasodilator, is used in cardiovascular and anorectal conditions. - Angina pectoris (prevention): provides prophylactic relief of chest pain episodes. - Angina pectoris (acute treatment): alleviates acute episodes of chest pain. - Anal fissure: relaxes the internal anal sphincter to facilitate healing and pain relief.

Common Side Effects: - Headache: mild to moderate throbbing pain. - Flushing: warmth and redness of the skin. - Dizziness: sensation of light‑headedness. - Hypotension: transient drop in blood pressure. - Tachycardia: increased heart rate. - Nausea: mild gastrointestinal upset.

Serious or Rare Side Effects: - Severe hypotension: marked blood pressure fall requiring medical attention. - Syncope: fainting episodes. - Myocardial infarction: rare but possible cardiac event. - Allergic reaction: rash, itching, or swelling. - Methemoglobinemia: rare blood disorder causing cyanosis.

Before using this product, consider the following safety measures. - Recent myocardial infarction: avoid use in patients with recent heart attack. - Concomitant nitrate therapy: risk of additive hypotension. - Phosphodiesterase‑5 inhibitors: contraindicated due to severe hypotension. - Hypotension monitoring: observe blood pressure after application. - Pregnancy and lactation: safety not established; use only if clearly needed. - Store at room temperature: keep in original container, protect from moisture and light.

Isosorbide dinitrate may interact with several medicines; review patient medication lists. Major Interactions (Avoid): - Phosphodiesterase‑5 inhibitors (e.g., sildenafil, tadalafil): can cause profound hypotension. - Other nitrates (e.g., nitroglycerin, isosorbide mononitrate): additive vasodilatory effect. - Guanylate cyclase stimulators: may amplify nitric‑oxide pathway. Moderate Interactions (Monitor Closely): - Antihypertensives (ACE inhibitors, beta‑blockers): may enhance blood‑pressure lowering. - Alcohol: can increase hypotensive effect. - CYP3A4 inhibitors (e.g., erythromycin, ketoconazole): may raise nitrate levels.