Europe — EMA
Isosorbide-5-Mononitraat Accord
Isosorbide Mononitrate, the active ingredient in Isosorbide-5-Mononitraat Accord, is a nitrate vasodilator presented as an oral tablet for oral administration. It is used to manage chronic stable angina pectoris by impr…
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What is Isosorbide Mononitrate?
Isosorbide Mononitrate, the active ingredient in Isosorbide-5-Mononitraat Accord, is a nitrate vasodilator presented as an oral tablet for oral administration. It is used to manage chronic stable angina pectoris by improving myocardial oxygen supply in adult patients.
GNH USA supplies Isosorbide-5-Mononitraat Accord as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality and regulatory compliance across global markets. The company adheres to stringent manufacturing standards and provides reliable logistics for timely delivery.
What is Isosorbide Mononitrate used for?
Isosorbide Mononitrate is an anti‑anginal nitrate used in the management of coronary artery disease.
- Chronic stable angina pectoris: reduces the frequency of angina attacks and improves exercise tolerance. - Effort‑induced angina: alleviates chest pain that occurs during physical exertion. - Angina prophylaxis: provides long‑term prevention of angina episodes in patients with established disease.
What are the side effects of Isosorbide Mononitrate?
Isosorbide Mononitrate may cause a range of adverse reactions, most of which are dose‑related and reversible.
Common Side Effects: - Headache: throbbing pain often occurring shortly after dosing. - Dizziness: sensation of light‑headedness, especially when standing quickly. - Flushing: warm feeling and reddening of the skin. - Nausea: mild stomach upset that may resolve with continued therapy.
Serious or Rare Side Effects: - Severe hypotension: marked drop in blood pressure that can cause fainting. - Syncope: sudden loss of consciousness related to low blood pressure. - Allergic reaction: rash, itching, or swelling indicating hypersensitivity.
What precautions apply to Isosorbide Mononitrate?
Before prescribing Isosorbide Mononitrate, clinicians should consider several safety measures.
- Assess cardiovascular status: evaluate blood pressure and heart rate prior to initiation. - Avoid concurrent use with PDE‑5 inhibitors: risk of profound hypotension. - Monitor for tolerance
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