Isopuramin

Glycine, the active ingredient in Isopuramin, is a amino acid supplement presented as a sterile intravenous solution for intravenous use. It provides a balanced mixture of essential and conditionally essential amino acids to support protein synthesis and metabolic functions in patients requiring parenteral nutrition.

GNH USA supplies Isopuramin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Isopuramin is used in clinical nutrition to address protein and amino‑acid deficits in patients who cannot receive enteral feeding. - Parenteral nutrition: Supplies essential amino acids to meet protein requirements in patients dependent on intravenous feeding. - Critical illness: Helps maintain nitrogen balance and supports tissue repair in severely ill or trauma patients. - Post‑operative recovery: Provides amino acids needed for wound healing and metabolic stability after major surgery.

Adverse reactions may occur with intravenous amino‑acid preparations and should be monitored.

Common Side Effects: - Infusion site phlebitis: redness or pain at the catheter site. - Mild hyperglycemia: transient elevation of blood glucose levels. - Electrolyte disturbances: shifts in potassium, calcium, or magnesium. - Nausea or mild gastrointestinal discomfort. - Headache or dizziness during infusion.

Serious or Rare Side Effects: - Anaphylactic reaction: severe hypersensitivity requiring immediate medical intervention. - Metabolic acidosis: significant pH imbalance in blood. - Hyperammonemia: elevated ammonia levels, particularly in hepatic impairment. - Renal dysfunction: worsening kidney function in susceptible patients. - Severe electrolyte imbalance: life‑threatening potassium or calcium abnormalities.

Careful assessment and monitoring are required when administering Isopuramin. - Renal function: evaluate renal status before initiation and monitor creatinine levels during therapy. - Electrolyte balance: check serum electrolytes prior to and throughout treatment. - Hepatic impairment: avoid or adjust dosing in patients with severe liver disease. - Allergy: screen for known hypersensitivity to any amino acid components. - Compatibility: verify compatibility with other intravenous solutions before co‑administration. - Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Isopuramin may interact with other agents affecting metabolic or renal pathways.

Major Interactions (Avoid): - Nephrotoxic drugs (e.g., aminoglycosides): may exacerbate renal load and impair clearance. - High‑dose insulin therapy: can precipitate severe hypoglycemia when combined with amino‑acid‑induced glucose shifts.

Moderate Interactions (Monitor Closely): - Diuretics: may increase risk of electrolyte disturbances; monitor serum levels. - Corticosteroids: can augment protein catabolism, potentially altering amino‑acid requirements. - Other parenteral nutrition components: ensure total nitrogen and caloric balance to avoid overload.