Isoptin Sr

Verapamil Hydrochloride, the active ingredient in Isoptin Sr, is a calcium channel blocker presented as an oral tablet for systemic use. It is employed to manage hypertension, angina pectoris, and certain cardiac arrhythmias such as atrial fibrillation and supraventricular tachycardia.

GNH USA supplies Isoptin Sr as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality manufacturing according to EU standards and reliable global distribution.

Verapamil is a calcium channel blocker used to treat cardiovascular conditions that involve elevated blood pressure or abnormal heart rhythms.

Hypertension: lowers blood pressure by causing peripheral vasodilation. Angina pectoris: reduces myocardial oxygen demand and relieves chest pain. Atrial fibrillation: slows atrioventricular nodal conduction to control ventricular rate. Supraventricular tachycardia: terminates episodes by decreasing AV nodal conduction.

Common Side Effects: - Constipation - Dizziness - Headache - Flushing - Peripheral edema - Nausea

Serious or Rare Side Effects: - Severe bradycardia - Heart block - Marked hypotension - Myocardial depression - Hepatic dysfunction - Allergic reactions such as rash or angioedema

Precautions should be observed when initiating or adjusting therapy with Isoptin Sr.

Monitor blood pressure: check regularly during therapy. Assess cardiac function: use caution in patients with heart failure or conduction disorders. Review drug history: avoid concomitant use with beta‑blockers or digoxin without supervision. Pregnancy considerations: limited data, prescribe only if benefit outweighs risk. Renal/hepatic impairment: dose may need adjustment in severe dysfunction. Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture.

Verapamil has several clinically important drug interactions that require attention.

Major Interactions (Avoid): - Concurrent use with strong CYP3A4 inhibitors (e.g., ketoconazole) may cause toxicity. - Co‑administration with beta‑blockers can lead to excessive bradycardia. - Combined with digoxin increases risk of digoxin toxicity. - Use with diltiazem may cause severe hypotension and AV block. - Concomitant use with certain antiarrhythmics (e.g., quinidine) can precipitate arrhythmias.

Moderate Interactions (Monitor Closely): - CYP3A4 inducers (e.g., rifampin) may reduce efficacy. - NSAIDs may blunt antihypertensive effect. - Alcohol may increase dizziness. - Lithium levels may rise when used together. - Statins metabolized by CYP3A4 may have increased plasma concentrations.