Isoptin Mite

Verapamil Hydrochloride, the active ingredient in Isoptin Mite, is a calcium channel blocker presented as an oral tablet for oral use. It belongs to the antiarrhythmic and antihypertensive therapeutic classes and is used to treat hypertension, angina pectoris, atrial fibrillation and supraventricular tachycardia in adult patients.

GNH USA supplies Isoptin Mite as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality and regulatory conformity across global markets. Our distribution network adheres to stringent quality standards and provides reliable logistics support.

Verapamil, a calcium channel blocker, is indicated for several cardiovascular conditions.

Hypertension: reduces elevated blood pressure by causing peripheral vasodilation. Angina pectoris: relieves chest pain by improving myocardial oxygen supply. Atrial fibrillation: controls ventricular rate by slowing atrioventricular nodal conduction. Supraventricular tachycardia: terminates rapid episodes by reducing AV nodal conduction.

Verapamil may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects: - Constipation: mild gastrointestinal discomfort. - Dizziness: light‑headedness, especially upon standing. - Headache: transient cranial pain. - Peripheral edema: swelling of ankles or feet. - Flushing: warm sensation and reddening of skin.

Serious or Rare Side Effects: - Bradycardia: abnormally slow heart rate. - Heart block: impaired electrical conduction. - Severe hypotension: marked drop in blood pressure.

When prescribing Verapamil, clinicians should consider several precautionary measures to ensure patient safety.

Cardiac function: assess for existing heart block or severe left ventricular dysfunction. Hepatic impairment: use with caution in patients with liver disease. Renal impairment: dose may need adjustment in severe renal failure. Drug interactions: review concomitant medications that affect cardiac conduction. Pregnancy and lactation: avoid unless benefit outweighs risk (unknown category). Store at ambient temperature: keep below 25°C in original packaging, protect from moisture.

Verapamil can interact with a variety of medicines; some require avoidance while others need careful monitoring.

Major Interactions (Avoid): - Beta‑blockers: combined use may cause profound bradycardia or heart block. - Digoxin: increased serum levels leading to toxicity. - CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): raise verapamil concentrations.

Moderate Interactions (Monitor Closely): - Antihypertensives (e.g., ACE inhibitors, diuretics): may enhance hypotensive effect. - Statins metabolized by CYP3A4 (e.g., simvastatin): increased risk of myopathy. - Calcium channel blocker combinations (e.g., diltiazem): additive cardiac effects.