Isolyte

Magnesium chloride hexahydrate, potassium chloride, sodium chloride, calcium chloride dihydrate and glucose, the active ingredients in Isolyte, are an electrolyte solution presented as a solution for injection for intravenous use. It provides fluid and electrolyte replacement in patients requiring rehydration, peri‑operative management or correction of electrolyte disturbances.

GNH USA supplies Isolyte as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Isolyte is an isotonic electrolyte solution used to address fluid and electrolyte deficits across several clinical settings. - Fluid replacement: restores intravascular volume and supports hemodynamic stability. - Electrolyte replenishment: corrects deficits of sodium, potassium, calcium, magnesium and glucose. - Dehydration treatment: rehydrates patients with fluid loss due to illness or surgery. - Peri‑operative fluid balance: maintains appropriate fluid status during surgical procedures.

Isolyte may be associated with a range of infusion‑related reactions.

Common Side Effects: - Infusion site irritation or pain. - Mild hypernatremia or hyponatremia. - Transient hyperkalemia. - Slight hypocalcemia. - Nausea or mild vomiting. - Light‑headedness or mild hypotension.

Serious or Rare Side Effects: - Severe hypermagnesemia leading to cardiac conduction abnormalities. - Life‑threatening hyperkalemia causing arrhythmias. - Anaphylactic or severe allergic reaction. - Fluid overload with pulmonary edema. - Metabolic acidosis. - Cardiac arrest due to electrolyte imbalance.

Before administering Isolyte, consider the following precautions. - Renal impairment: monitor electrolyte levels closely. - Cardiac disease: assess baseline potassium and magnesium. - Pregnancy: use only if clearly needed after risk‑benefit evaluation. - Concomitant electrolyte supplements: avoid duplicate dosing. - Infusion rate: follow prescribed rate to prevent rapid shifts. - Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Isolyte can interact with other medications that affect electrolyte balance.

Major Interactions (Avoid): - ACE inhibitors: increased risk of hyperkalemia. - Potassium‑sparing diuretics: additive potassium load. - Loop diuretics: may exacerbate electrolyte disturbances. - Magnesium‑containing antacids: risk of hypermagnesemia.

Moderate Interactions (Monitor Closely): - Insulin therapy: may cause rapid intracellular potassium shift. - Beta‑agonists: can lower serum potassium. - Blood transfusions: citrate may bind calcium, altering calcium levels.