GNH USA

Europe — EMA

Isodol (Nimesulide)

GNH USA supplies Isodol (Nimesulide), a non‑steroidal anti‑inflammatory drug for mild to moderate pain, osteoarthritis and dysmenorrhea. Request a quote.

Nimesulide

Request sourcing

1
Pack/s

What is Nimesulide?

Nimesulide, the active ingredient in Isodol, is a non‑steroidal anti‑inflammatory drug presented as an oral tablet for systemic use. It is indicated for the relief of mild to moderate pain, inflammation associated with osteoarthritis, and dysmenorrhea in adult patients.

GNH USA supplies Isodol as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory‑approved batches for global distribution. Clients benefit from reliable logistics, comprehensive documentation, and responsive technical support throughout the procurement process.

What is Nimesulide used for?

Nimesulide acts by inhibiting cyclo‑oxygenase‑2, reducing prostaglandin‑mediated inflammation and pain.

- Mild to moderate pain: provides analgesic relief in conditions such as headache, dental pain, and musculoskeletal discomfort. - Osteoarthritis: decreases joint inflammation and improves functional mobility in patients with degenerative joint disease. - Dysmenorrhea: alleviates menstrual cramps by reducing uterine prostaglandin production.

What are the side effects of Nimesulide?

Nimesulide may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects: - Gastrointestinal discomfort: nausea, dyspepsia or abdominal pain. - Headache: mild to moderate intensity. - Dizziness or vertigo. - Skin rash: mild erythema or itching. - Elevated liver enzymes: transient increase detected in laboratory tests.

Serious or Rare Side Effects: - Hepatotoxicity: severe liver injury or failure. - Severe allergic reactions: anaphylaxis or Stevens‑Johnson syndrome. - Renal impairment: acute kidney injury or reduced renal function. - Cardiovascular events: increased risk of myocardial infarction or stroke.

What precautions apply to Nimesulide?

When prescribing Isodol, clinicians should consider several safety measures.

- Assess renal and hepatic function: evaluate baseline kidney and liver tests before initiating therapy. - Avoid in patients with known hypersensitivity to nimesulide or other NSAIDs. - Use the lowest effective dose for the shortest duration: limit exposure to reduce risk of adverse effects. - Caution in elderly patients: monitor for gastrointestinal bleeding and renal dysfunction. - Concomitant anticoagulants or antiplatelet agents: increase bleeding risk, require close monitoring. - Store at room temperature below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

What does Nimesulide interact with?

Nimesulide can interact with several drug classes, requiring careful management.

Major Interactions (Avoid): - Concurrent use with other NSAIDs or COX‑2 inhibitors: additive risk of gastrointestinal bleeding and renal toxicity. - Combination with anticoagulants (e.g., warfarin) or antiplatelet drugs: heightened bleeding tendency. - Co‑administration with hepatotoxic agents (e.g., isoniazid, methotrexate): increased risk of liver injury.

Moderate Interactions (Monitor Closely): - Diuretics or ACE inhibitors: may reduce renal perfusion, monitor kidney function. - Lithium therapy: NSAIDs can increase lithium levels, check serum concentrations. - Corticosteroids: combined use may exacerbate gastrointestinal ulcer risk.

Frequently asked questions

What is Isodol used for?+
Isodol contains the active ingredient nimesulide and is prescribed to relieve mild to moderate pain, reduce inflammation in osteoarthritis, and alleviate menstrual cramps (dysmenorrhea). It is typically used in adult patients when a selective COX‑2 inhibitor is appropriate for managing these conditions.
How does Nimesulide work?+
Nimesulide works by selectively inhibiting the cyclo‑oxygenase‑2 (COX‑2) enzyme, which is responsible for converting arachidonic acid into prostaglandins that cause inflammation, pain, and fever. By blocking COX‑2, the drug lowers prostaglandin levels, thereby reducing the inflammatory response and providing analgesic effects.
What is the usual dose of Isodol?+
The specific dose of Isodol is determined by the prescribing healthcare professional based on the patient’s condition, age, weight, and overall health status. Dosage instructions are provided on the prescription label and should be followed exactly as directed by the prescriber.
Is Isodol safe in pregnancy or breastfeeding?+
Safety data for nimesulide during pregnancy and lactation are limited, and the drug is generally not recommended for use in pregnant or breastfeeding women unless the potential benefit outweighs the risk. Physicians should evaluate each case individually and consider alternative therapies when possible.
How do I order Isodol from GNH USA?+
To order Isodol, submit an enquiry on the product page at gnh-usa.com specifying the required quantity. GNH USA supplies hospitals, pharmacies and procurement teams worldwide and will request verification of trade or institutional credentials. The sales team then provides pricing, availability, shipping details and any necessary import documentation.
How does Isodol compare with other NSAIDs?+
Isodol (nimesulide) is a selective COX‑2 inhibitor, which may offer a lower risk of gastrointestinal irritation compared with non‑selective NSAIDs such as ibuprofen or diclofenac. However, it carries its own safety considerations, including potential liver toxicity, and should be chosen based on the patient’s overall risk profile and therapeutic needs.
How should Isodol be stored and handled?+
Isodol tablets should be stored at room temperature below 25 °C, kept in the original packaging to protect from moisture and direct sunlight. Ensure the container is tightly closed and out of reach of children. Do not use the product after the expiry date printed on the label.
How is Isodol administered?+
Isodol is taken orally, usually with a full glass of water. It can be taken with or without food, but patients who experience stomach upset may benefit from taking the tablet with meals. Swallow the tablet whole; do not crush, chew, or split it unless instructed by a healthcare professional.
What are the most serious risks associated with Isodol?+
The most serious risks linked to Isodol include severe liver injury (hepatotoxicity), life‑threatening allergic reactions such as anaphylaxis or Stevens‑Johnson syndrome, and rare cardiovascular events like myocardial infarction or stroke. Patients should be monitored for signs of liver dysfunction, rash, or chest pain, and the drug should be discontinued immediately if serious adverse events occur.
Who should not use Isodol?+
Isodol should be avoided in individuals with known hypersensitivity to nimesulide or other NSAIDs, patients with active peptic ulcer disease, severe liver impairment, or uncontrolled heart failure. It is also contraindicated in patients taking certain anticoagulants or other COX‑2 inhibitors without close medical supervision.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
Send a sourcing enquiry for this product →

Product details

Drug
Nimesulide
Route
Oral Use
Manufacturer
Aesculapius Farmaceutici S.R.L.
Origin
EU

Related products

Actalide

Actalide

Nimesulide

Errekappa Euroterapici Spa
EU
Actalide

Actalide

Nimesulide

Errekappa Euroterapici Spa
EU
Algolider

Algolider

Nimesulide

Siar Pharma S.R.L.
EU
Aponil

Aponil

Nimesulide

Medochemie Ltd.
EU