Ismox Depot

Isosorbide 5 Mononitrate, the active ingredient in Ismox Depot, is a nitrate vasodilator presented as an oral tablet for oral use. It is employed in the prophylaxis and treatment of angina pectoris, helping to reduce the frequency of chest pain episodes in patients with chronic stable angina.

GNH USA supplies Ismox Depot as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Ismox Depot, a nitrate vasodilator, is indicated for conditions involving myocardial ischemia and angina. - Prophylaxis of angina pectoris: reduces the frequency of angina attacks during daily activities. - Treatment of chronic stable angina: improves exercise tolerance and decreases symptom burden. - Management of coronary artery disease: alleviates myocardial oxygen demand by lowering preload and afterload.

Ismox Depot may cause a range of adverse reactions. Patients should be aware of both common and serious possibilities.

Common Side Effects: - Headache: mild to moderate, often transient. - Dizziness or light‑headedness: related to blood pressure lowering. - Flushing: warm sensation, especially after the first dose. - Nausea: occasional gastrointestinal upset. - Palpitations: awareness of heartbeat changes.

Serious or Rare Side Effects: - Severe hypotension: marked drop in blood pressure requiring medical attention. - Syncope: fainting episodes due to inadequate cerebral perfusion. - Allergic reactions: rash, itching, or swelling that may progress to anaphylaxis. - Methemoglobinemia: rare blood disorder causing reduced oxygen delivery. - Myocardial infarction: extremely rare but reported in susceptible individuals.

Before initiating therapy with Ismox Depot, consider the following safety measures. - Discontinue use gradually: avoid abrupt cessation to prevent rebound angina. - Monitor blood pressure: watch for symptomatic hypotension, especially after the first dose. - Hepatic impairment: use cautiously, as metabolism may be altered. - Concomitant PDE‑5 inhibitors: avoid combined use due to risk of severe hypotension. - Pregnancy and lactation: safety not established; discuss risks with a healthcare professional. - Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Ismox Depot can interact with several drug classes; awareness helps prevent adverse events.

Major Interactions (Avoid): - Other nitrates (e.g., isosorbide dinitrate): additive vasodilatory effect leading to profound hypotension. - Phosphodiesterase‑5 inhibitors (e.g., sildenafil): risk of severe blood pressure fall. - Antihypertensive agents (e.g., ACE inhibitors, beta‑blockers): may cause excessive blood pressure reduction.

Moderate Interactions (Monitor Closely): - Alcohol: can enhance hypotensive response. - Diuretics: may increase dehydration and lower blood pressure. - Beta‑blockers: additive effect on heart rate and blood pressure, requiring dose adjustments.