Ismo Retard

Isosorbide Mononitrate, the active ingredient in Ismo Retard, is an organic nitrate presented as an oral tablet for oral use. It is used to prevent and treat stable angina pectoris in adults.

GNH USA supplies Ismo Retard as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Isosorbide Mononitrate is employed in the management of coronary artery disease and related angina syndromes.

- Stable angina pectoris: reduces the frequency of angina attacks and improves exercise tolerance. - Chronic stable angina: provides prophylactic relief of chest pain during daily activities. - Angina due to coronary artery disease: decreases myocardial oxygen demand by lowering cardiac preload and afterload.

Common side effects are generally mild and related to the vasodilatory action of the drug.

Common Side Effects: - Headache - Dizziness - Flushing - Hypotension - Nausea - Palpitations

Serious or Rare Side Effects: - Severe hypotension - Syncope (fainting) - Myocardial infarction - Life‑threatening arrhythmias - Anaphylactic or severe allergic reaction - Methemoglobinemia (rare)

Before initiating therapy, clinicians should evaluate cardiovascular status and consider concomitant medications.

- Assess blood pressure: ensure baseline values are within safe limits before starting. - Avoid abrupt discontinuation: sudden stop may precipitate rebound angina. - Concomitant nitrate therapy: increases risk of profound hypotension. - Renal impairment: monitor renal function and adjust dose if needed. - Hepatic impairment: use with caution and observe for increased exposure. - Store at ambient temperature below 25°C: keep in the original pack, protect from moisture.

Isosorbide Mononitrate can interact with several drug classes, requiring careful management.

Major Interactions (Avoid): - Other organic nitrates: additive vasodilatory effect causing severe hypotension. - Phosphodiesterase‑5 inhibitors (e.g., sildenafil): risk of profound hypotension. - Sodium nitrite: potentiates hypotensive response.

Moderate Interactions (Monitor Closely): - Antihypertensive agents: may enhance blood‑pressure‑lowering effect. - Diuretics: can increase the likelihood of orthostatic hypotension. - Alcohol: may augment vasodilatory side effects such as dizziness and flushing.