Ismo Retard

Isosorbide 5-Mononitrate, the active ingredient in Ismo Retard, is a nitrate vasodilator presented as an oral tablet for oral use. It works by donating nitric oxide to relax vascular smooth muscle, thereby reducing cardiac workload. The medication is indicated for the prevention of angina pectoris and for the long‑term management of chronic stable angina in adult patients.

GNH USA supplies Ismo Retard as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality and regulatory compliance across all markets.

Ismo Retard, a nitrate vasodilator, is used in the management of coronary artery disease‑related angina.

- Prevention of angina pectoris: reduces the frequency of angina attacks in patients with chronic stable angina. - Chronic stable angina: improves exercise tolerance and decreases myocardial oxygen demand. - Ischemic heart disease: provides symptomatic relief of chest pain associated with reduced coronary blood flow.

Ismo Retard may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects: - Headache - Dizziness - Flushing - Hypotension - Nausea - Palpitations

Serious or Rare Side Effects: - Severe hypotension - Syncope - Myocardial infarction - Severe allergic reaction (anaphylaxis) - Tachycardia - Worsening of angina

When prescribing Ismo Retard, clinicians should observe several precautionary measures to ensure patient safety.

- Monitor blood pressure: check for hypotension especially after the first dose. - Avoid abrupt discontinuation: taper to prevent rebound angina. - Use with caution in hepatic impairment: dose adjustment may be required. - Assess concomitant use of phosphodiesterase‑5 inhibitors: increased risk of severe hypotension. - Avoid concurrent nitrates: risk of additive vasodilation. - Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Ismo Retard can interact with several drug classes, requiring careful management.

Major Interactions (Avoid): - Other nitrate preparations: additive vasodilatory effect leading to severe hypotension. - Phosphodiesterase‑5 inhibitors (e.g., sildenafil, tadalafil): risk of profound hypotension. - Sodium nitroprusside: excessive vasodilation.

Moderate Interactions (Monitor Closely): - Antihypertensive agents (ACE inhibitors, ARBs, calcium channel blockers): may enhance blood pressure lowering. - Diuretics: can potentiate orthostatic hypotension. - Beta‑blockers: may mask tachycardia signs of hypotension.