Ismo

Isosorbide 5-mononitrate, the active ingredient in Ismo, is a nitrate vasodilator presented as an oral tablet for oral use. It is employed to prevent and treat episodes of angina pectoris in adults with coronary artery disease by reducing myocardial oxygen demand.

GNH USA supplies Ismo as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring consistent quality, reliable delivery, and comprehensive support for regulatory and procurement documentation.

Ismo, a nitrate vasodilator, is used in the management of angina‑related conditions.

Stable angina pectoris: reduces frequency and severity of chest‑pain episodes. Chronic stable angina: improves exercise tolerance and delays onset of pain. Exercise‑induced angina: prevents pain during physical exertion.

Ismo may cause a range of adverse reactions, which are grouped by frequency.

Common Side Effects: - Headache: often transient and dose‑related. - Flushing: warm sensation, usually mild. - Dizziness or light‑headedness. - Nausea: occasional gastrointestinal upset.

Serious or Rare Side Effects: - Severe hypotension: marked drop in blood pressure requiring medical attention. - Syncope: fainting episodes due to low blood pressure. - Allergic reactions: rash, angioedema, or anaphylaxis in rare cases.

When prescribing Ismo, clinicians should consider several safety measures.

Avoid abrupt discontinuation: may precipitate recurrence of angina. Monitor blood pressure: risk of hypotension, especially in volume‑depleted patients. Use with caution in hepatic impairment: altered drug metabolism may increase exposure. Avoid concurrent use with phosphodiesterase‑5 inhibitors: risk of profound hypotension. Pregnancy and lactation: safety not established; use only if benefit outweighs risk. Store at ambient temperature below 25°C: keep in original packaging, protect from moisture.

Ismo can interact with several drug classes, requiring careful management.

Major Interactions (Avoid): - Sildenafil, tadalafil, and other PDE‑5 inhibitors: may cause severe hypotension. - Other nitrates (e.g., nitroglycerin, isosorbide dinitrate): additive vasodilatory effect leading to dangerous blood‑pressure drops.

Moderate Interactions (Monitor Closely): - Antihypertensive agents (beta‑blockers, ACE inhibitors, ARBs): may enhance blood‑pressure‑lowering effect. - Alcohol: can increase vasodilatory response and dizziness. - Diuretics: may potentiate hypotensive effect, requiring blood‑pressure monitoring.