Ismo

Isosorbide 5-mononitrate, the active ingredient in Ismo, is an organic nitrate vasodilator presented as an oral tablet for oral administration. It works by dilating coronary vessels and reducing cardiac workload, thereby preventing and relieving episodes of angina pectoris in adults with coronary artery disease.

GNH USA supplies Ismo as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring consistent quality, regulatory compliance, and reliable delivery across global markets.

Isosorbide 5-mononitrate is used in the management of coronary artery disease‑related angina, reducing myocardial oxygen demand.

- Stable angina: reduces frequency and severity of chest‑pain episodes. - Chronic angina: provides long‑term prophylaxis against angina attacks. - Effort‑induced angina: improves exercise tolerance by decreasing cardiac workload.

Isosorbide 5‑mononitrate may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects: - Headache: throbbing pain often occurring after the first dose. - Dizziness: light‑headed sensation, especially on standing. - Flushing: warmth and redness of the face or neck. - Nausea: mild stomach upset.

Serious or Rare Side Effects: - Severe hypotension: marked drop in blood pressure requiring medical attention. - Syncope: sudden loss of consciousness. - Allergic reaction: rash, itching, swelling, or difficulty breathing.

When prescribing Isosorbide 5‑mononitrate, clinicians should consider several safety measures.

- Use with caution in patients with severe hypotension: monitor blood pressure regularly. - Avoid concurrent use with other nitrates: risk of additive vasodilation. - Do not combine with phosphodiesterase‑5 inhibitors (e.g., sildenafil): may cause profound hypotension. - Adjust dose in hepatic impairment: reduced clearance may increase exposure. - Monitor for signs of tolerance: efficacy may diminish with continuous use. - Store at room temperature: keep in the original container, protect from moisture and light.

Isosorbide 5‑mononitrate interacts with several drug classes; awareness helps prevent adverse events.

Major Interactions (Avoid): - Sildenafil and other PDE5 inhibitors: can cause dangerous hypotension. - Other nitrate preparations (nitroglycerin, isosorbide dinitrate): additive vasodilatory effect. - Antihypertensive agents in high doses: may lead to excessive blood‑pressure drop.

Moderate Interactions (Monitor Closely): - Beta‑blockers: may enhance bradycardia. - Calcium channel blockers: can increase risk of hypotension. - Alcohol: may intensify vasodilatory effects and dizziness.