Ismo

Isosorbide 5-Mononitrate, the active ingredient in Ismo, is an organic nitrate presented as an oral tablet for oral use. It is indicated for the prevention of angina pectoris and for chronic stable angina in adult patients. It works by releasing nitric oxide, which relaxes vascular smooth muscle and improves myocardial oxygen balance.

GNH USA supplies Ismo as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable logistics for global distribution.

Ismo, an organic nitrate, is used in the management of angina-related conditions.

Prevention of angina pectoris: reduces the frequency and severity of angina attacks during daily activities. Chronic stable angina: alleviates chest pain and improves exercise tolerance in patients with stable coronary disease. Exercise‑induced angina: provides prophylactic relief during physical exertion.

Isosorbide 5‑Mononitrate may cause a range of adverse reactions, which are grouped by frequency.

Common Side Effects: - Headache - Dizziness - Flushing - Hypotension - Nausea - Palpitations

Serious or Rare Side Effects: - Severe hypotension - Syncope - Myocardial infarction - Allergic reactions (rash, angioedema) - Methemoglobinemia - Tachycardia

When prescribing Ismo, clinicians should consider several safety measures.

Assess blood pressure: measure baseline systolic and diastolic values before starting therapy. Avoid concurrent nitrates: combined use can cause excessive vasodilation and profound hypotension. Limit alcohol intake: alcohol may potentiate hypotensive effects. Monitor for tolerance: efficacy may diminish with prolonged use, requiring dose adjustment. Store at ambient temperature: keep below 25 °C, retain in original container, protect from moisture.

Ismo can interact with other medicines, necessitating careful review.

Major Interactions (Avoid): - Sildenafil and other PDE5 inhibitors: risk of severe hypotension. - Other organic nitrates (e.g., nitroglycerin): additive vasodilatory effect leading to dangerous blood pressure drop. - Alcohol: may intensify hypotensive response.

Moderate Interactions (Monitor Closely): - Antihypertensive agents (ACE inhibitors, beta‑blockers): may require blood pressure monitoring and dose adjustment. - Diuretics: monitor electrolytes and renal function when combined.