GNH USA

Europe — EMA

Isentress

GNH USA supplies Isentress (Raltegravir), an integrase strand transfer inhibitor for HIV‑1 infection, to hospitals and clinics globally. Request a quote.

Raltegravir

Request sourcing

1
Pack/s

What is Raltegravir?

Raltegravir, the active ingredient in Isentress, is an integrase strand transfer inhibitor (INSTI) presented as a 400 mg tablet for oral use. It treats HIV‑1 infection in adults and adolescents and is indicated for use in combination with other antiretroviral agents. GNH USA supplies Isentress as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, adhering to EU quality standards and providing regulatory documentation for importers.

What is Raltegravir used for?

Isentress (raltegravir) is used in the management of HIV‑1 infection, targeting the viral integrase enzyme.

HIV‑1 infection (treatment‑naïve adults and adolescents): provides viral suppression when combined with other antiretrovirals. HIV‑1 infection (treatment‑experienced patients with resistance): offers an alternative regimen for resistant virus. HIV‑1 infection (pediatric patients ≥2 years): enables weight‑based dosing in combination therapy.

What are the side effects of Raltegravir?

Common and serious adverse reactions have been reported with raltegravir.

Common Side Effects: - Nausea: mild gastrointestinal upset. - Diarrhea: loose stools. - Headache: mild to moderate. - Fatigue: general tiredness.

Serious or Rare Side Effects: - Anaphylaxis: severe allergic reaction requiring immediate medical attention. - Hepatic failure: signs of liver dysfunction. - Rhabdomyolysis: muscle breakdown with elevated creatine kinase. - Stevens‑Johnson syndrome: severe skin reaction.

What precautions apply to Raltegravir?

When prescribing Isentress, consider the following precautions. - Pregnancy: category B1, use only if benefit outweighs risk. - Breastfeeding: limited data, evaluate risk/benefit before use. - Renal impairment: dose adjustment may be required. - Hepatic impairment: monitor liver function regularly. - Drug resistance: avoid monotherapy to prevent resistance development. - Store at room temperature: keep below 25 °C, retain in original packaging, protect from moisture.

What does Raltegravir interact with?

Raltegravir may interact with several concomitant medicines.

Major Interactions (Avoid): - Antacids containing aluminum or magnesium: reduce raltegravir absorption. - Cobicistat‑containing regimens: may increase raltegravir exposure.

Moderate Interactions (Monitor Closely): - Carbamazepine: may lower raltegravir plasma levels. - St. John’s wort: may decrease raltegravir exposure. - Methadone: may require dose adjustment when co‑administered.

Frequently asked questions

What is Isentress used for?+
Isentress, containing the active ingredient raltegravir, is prescribed for the treatment of HIV‑1 infection. It is used as part of combination antiretroviral therapy to achieve viral suppression in both treatment‑naïve and treatment‑experienced patients, including adults, adolescents, and children aged two years and older.
How does raltegravir work?+
Raltegravir works by selectively inhibiting the HIV‑1 integrase enzyme, which is essential for inserting viral DNA into the host cell genome. By blocking the strand‑transfer step, the drug prevents the integration of viral genetic material, thereby halting replication of the virus when used with other antiretrovirals.
What is the usual dose of Isentress?+
The dosing regimen for Isentress is determined by the prescribing clinician based on the patient’s age, weight, renal and hepatic function, and the overall antiretroviral regimen. Healthcare providers follow approved guidelines to select the appropriate dose and schedule for each individual.
Is Isentress safe during pregnancy and breastfeeding?+
Isentress is classified as pregnancy category B1, indicating that animal studies have not shown risk and there are no well‑controlled studies in pregnant women. It may be used during pregnancy only if the potential benefit justifies the potential risk. Limited data are available for breastfeeding; clinicians should weigh the benefits against possible risks to the infant.
How do I order Isentress from GNH USA?+
To order Isentress, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA supplies hospitals, pharmacies and procurement teams across international markets. After the request, the sales team will verify trade or institutional credentials, then provide pricing, availability, shipping details (including any required temperature control) and assist with import documentation.
How does Isentress compare with the main alternative drug or class?+
Isentress belongs to the integrase strand transfer inhibitor (INSTI) class, similar to dolutegravir and elvitegravir. Compared with earlier INSTIs, raltegravir has a well‑established safety profile and a lower barrier to resistance than dolutegravir, but may require twice‑daily dosing. Choice of agent depends on resistance patterns, patient comorbidities, and convenience considerations.
How should Isentress be stored and handled?+
Isentress tablets should be stored at room temperature, below 25 °C, in their original blister pack to protect from moisture and light. Keep the product out of reach of children and avoid storing in areas with high humidity or direct sunlight.
How is Isentress administered?+
Isentress is taken orally as a tablet, usually with or without food according to the prescribing information. Patients should swallow the tablet whole with water and follow the dosing schedule set by their healthcare provider to maintain consistent drug levels.
What are the most serious risks to watch for while taking Isentress?+
Serious adverse reactions, although rare, include severe allergic responses such as anaphylaxis, hepatic failure, rhabdomyolysis, and severe skin conditions like Stevens‑Johnson syndrome. Patients should seek immediate medical attention if they experience symptoms such as rash, jaundice, muscle pain, or difficulty breathing.
Who should not use Isentress?+
Isentress should be avoided in individuals with known hypersensitivity to raltegravir or any tablet excipients. It is also contraindicated in patients who are unable to adhere to a combination antiretroviral regimen, as monotherapy can lead to rapid development of resistance.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
Send a sourcing enquiry for this product →

Product details

Drug
Raltegravir
Route
Oral Use
Manufacturer
Merck Sharp & Dohme B.V.
Origin
EU

Related products

A

A

Liquid Extract From Viscum Album Subsp. Abietis Var Abies Alba (1:20), Extraction Solvents: Water Fo

Helixor Heilmittel Gmbh
EU
A

A

Liquid Extract From Viscum Album Subsp. Abietis Var Abies Alba (1:20), Extraction Solvents: Water Fo

Helixor Heilmittel Gmbh
EU
A

A

Liquid Extract From Viscum Album Subsp. Abietis Var Abies Alba (1:20), Extraction Solvents: Water Fo

Helixor Heilmittel Gmbh
EU
A

A

Liquid Extract From Viscum Album Subsp. Abietis Var Abies Alba (1:20), Extraction Solvents: Water Fo

Helixor Heilmittel Gmbh
EU