Iruzid

Hydrochlorothiazide and Lisinopril, the active ingredients in Iruzid, are a thiazide diuretic and an ACE inhibitor presented as a fixed‑dose combination tablet for oral administration. The formulation is indicated for the management of hypertension and for reducing edema associated with heart failure in adult patients.

GNH USA supplies Iruzid as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality and regulatory compliance across all markets with reliable logistics and post‑delivery assistance.

Iruzid combines a thiazide diuretic and an ACE inhibitor to treat conditions related to elevated blood pressure and fluid retention.

- Hypertension: lowers systolic and diastolic blood pressure in adult patients. - Edema associated with heart failure: promotes diuresis and reduces fluid overload. - Fluid retention in hypertensive patients: improves blood pressure control while decreasing excess extracellular fluid.

Iruzid may cause a range of adverse reactions, from mild to severe.

Common Side Effects: - Dizziness or light‑headedness - Headache - Persistent dry cough - Increased urinary frequency - Electrolyte disturbances (e.g., low potassium) - Fatigue or weakness

Serious or Rare Side Effects: - Angioedema (swelling of face, lips, tongue) - Severe hypotension - Acute kidney injury or renal failure - Hyperkalemia (high potassium levels) - Severe dehydration - Pancreatitis (rare).

Before prescribing Iruzid, clinicians should consider several safety measures.

- Monitor blood pressure: ensure adequate control without excessive hypotension. - Assess renal function: check serum creatinine and eGFR regularly. - Check electrolytes: especially potassium and sodium levels. - Avoid use in pregnancy: category D indicates potential fetal risk. - Use cautiously in patients with diabetes or hepatic impairment. - Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Iruzid can interact with several medicines, requiring careful management.

Major Interactions (Avoid): - NSAIDs: may blunt antihypertensive effect and impair renal function. - Potassium‑sparing diuretics or supplements: increase risk of hyperkalemia. - Other ACE inhibitors or ARBs: heighten risk of renal insufficiency and hyperkalemia. - Lithium: can raise lithium serum concentrations.

Moderate Interactions (Monitor Closely): - Loop diuretics: may cause additive electrolyte loss. - Beta‑blockers: may enhance hypotensive response. - Antidiabetic agents: may require dose adjustment due to altered glucose control. - Contrast media: monitor renal function closely. - Antihistamines or other antihypertensives: watch for excessive blood pressure drop.