Iruzid (Hydrochlorothiazide, Lisinopril)

Hydrochlorothiazide / Lisinopril, the active ingredient in Iruzid, is a ACE inhibitor and thiazide diuretic combination presented as an oral tablet for oral use. It treats hypertension in adults.

GNH USA supplies Iruzid as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Iruzid is indicated for the management of hypertension, a condition involving elevated systemic arterial pressure. - Hypertension: reduces elevated blood pressure and helps achieve target levels. - Essential hypertension: provides combined ACE inhibition and diuresis to improve control. - Renin‑angiotensin system‑mediated hypertension: offers dual mechanism to lower systolic and diastolic pressures.

Iruzid may cause a range of adverse reactions, from mild to severe.

Common Side Effects: - Dizziness: sensation of light‑headedness, especially after standing. - Headache: mild to moderate pain in the head region. - Cough: dry, persistent cough associated with ACE inhibition. - Increased urination: due to the diuretic component. - Electrolyte imbalance: mild changes in potassium or sodium levels. - Fatigue: general feeling of tiredness.

Serious or Rare Side Effects: - Angioedema: swelling of face, lips, tongue, or throat that can compromise breathing. - Severe hypotension: marked drop in blood pressure causing fainting. - Acute kidney injury: sudden decline in renal function. - Hyperkalemia: dangerously high potassium levels. - Severe dehydration: excessive fluid loss leading to electrolyte disturbances. - Allergic reactions: rash, itching, or anaphylaxis.

Before initiating Iruzid, several safety considerations should be reviewed. - Renal function: monitor serum creatinine and eGFR regularly. - Electrolytes: check potassium and sodium levels, especially in patients on other diuretics. - Pregnancy: category D; avoid use unless benefits outweigh risks. - Concurrent ACE inhibitors or ARBs: increased risk of hyperkalemia and renal impairment. - Diabetes mellitus: monitor blood glucose as diuretics may affect control. - Store at ambient temperature: keep below 25°C in the original packaging, protected from moisture.

Iruzid can interact with several medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid): - Potassium‑sparing diuretics: risk of hyperkalemia. - NSAIDs: may blunt antihypertensive effect and affect renal function. - Lithium: increased lithium concentrations leading to toxicity.

Moderate Interactions (Monitor Closely): - Other antihypertensives: additive blood‑pressure lowering may cause hypotension. - Diabetes medications: diuretic effect may alter glucose control. - Corticosteroids: may increase sodium retention counteracting diuretic action.