GNH USA

Europe — EMA

Irbesartan/Hydroklortiazid Actavis (Hydrochlorothiazide, Irbesartan)

GNH USA supplies Irbesartan/HCTZ (Irbesartan/Hydrochlorothiazide), an ARB and thiazide diuretic for hypertension.

Hydrochlorothiazide, Irbesartan

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What is Hydrochlorothiazide, Irbesartan?

Irbesartan/Hydrochlorothiazide, the active ingredient in Irbesartan/Hydrochlorothiazide Actavis, is an angiotensin II receptor blocker combined with a thiazide diuretic presented as a tablet for oral use. It is prescribed to lower elevated blood pressure in adult patients with hypertension, often in those who require additional diuretic therapy.

GNH USA supplies Irbesartan/Hydrochlorothiazide Actavis as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Hydrochlorothiazide, Irbesartan used for?

Irbesartan/Hydrochlorothiazide is used to manage hypertension and related cardiovascular conditions. - Hypertension: lowers systolic and diastolic blood pressure in adults. - Hypertensive chronic kidney disease: helps control blood pressure and reduces proteinuria. - Hypertension in type 2 diabetes: improves blood pressure control and may protect renal function.

What are the side effects of Hydrochlorothiazide, Irbesartan?

The combination may cause a range of adverse reactions, varying in frequency and severity.

Common Side Effects: - Dizziness or light‑headedness - Headache - Fatigue - Increased urination - Electrolyte disturbances such as low potassium - Mild gastrointestinal upset

Serious or Rare Side Effects: - Severe hypotension - Acute kidney injury - Hyperkalemia - Significant electrolyte imbalance (e.g., hyponatremia) - Allergic reactions including rash or angioedema - Pancreatitis (rare)

What precautions apply to Hydrochlorothiazide, Irbesartan?

Before prescribing Irbesartan/Hydrochlorothiazide, clinicians should consider several safety precautions. - Renal function: assess kidney function and monitor serum creatinine. - Electrolytes: check potassium and sodium levels regularly. - Volume depletion: avoid in patients with dehydration or on high‑dose diuretics. - Pregnancy: contraindicated in the second and third trimesters; avoid use. - Concomitant drugs: review for interactions with potassium‑sparing agents or NSAIDs. - Store at ambient temperature: keep below 25 °C, protect from moisture in the original packaging.

What does Hydrochlorothiazide, Irbesartan interact with?

Irbesartan/Hydrochlorothiazide can interact with other medicines, affecting its efficacy or safety.

Major Interactions (Avoid): - Potassium‑sparing diuretics or supplements: risk of hyperkalemia. - ACE inhibitors or other ARBs: additive renal effects and hyperkalemia. - NSAIDs: may blunt antihypertensive effect and worsen renal function.

Moderate Interactions (Monitor Closely): - Lithium: increased lithium levels, monitor for toxicity. - Cyclosporine or tacrolimus: may increase serum creatinine. - Antidiabetic agents: diuretic‑induced glucose changes may require dose adjustment.

Frequently asked questions

What is Irbesartan/Hydrochlorothiazide used for?+
Irbesartan/Hydrochlorothiazide is an oral antihypertensive medication indicated for the treatment of high blood pressure in adults. It is often prescribed when a single‑agent therapy does not achieve target blood pressure, providing combined angiotensin II receptor blockade and diuretic action to improve control.
How does Irbesartan/Hydrochlorothiazide work?+
The combination works by two mechanisms: Irbesartan blocks the AT1 receptor, preventing angiotensin II‑driven vasoconstriction and aldosterone release, while Hydrochlorothiazide inhibits sodium‑chloride reabsorption in the distal tubule, increasing urine output and reducing blood volume. Together they lower peripheral resistance and intravascular volume, resulting in blood‑pressure reduction.
What determines the usual dose of Irbesartan/Hydrochlorothiazide?+
The appropriate dose is individualized by the prescribing clinician based on the patient’s blood‑pressure level, renal function, electrolyte status, and response to therapy. Dosage adjustments may be required for elderly patients or those with impaired kidney function, and the prescriber will decide the exact strength and frequency.
Is Irbesartan/Hydrochlorothiazide safe during pregnancy or breastfeeding?+
Irbesartan/Hydrochlorothiazide is generally contraindicated in the second and third trimesters of pregnancy because of potential fetal toxicity. Safety during breastfeeding has not been established, and clinicians usually advise against its use in nursing mothers unless the benefits clearly outweigh the risks.
How do I order Irbesartan/Hydrochlorothiazide from GNH USA?+
To place an order, submit an enquiry on the product page at gnh-usa.com specifying the required quantity. GNH USA supplies hospitals, pharmacies and procurement teams worldwide, and will request verification of trade or institutional credentials. After confirmation, the sales team provides pricing, availability, shipping details and any necessary import documentation.
How does Irbesartan/Hydrochlorothiazide compare with other antihypertensive options?+
Compared with monotherapy agents, the Irbesartan/Hydrochlorothiazide combo offers additive blood‑pressure lowering effects, often achieving target control with a single pill. It may be preferred over separate tablets for convenience and adherence. Relative to other ARB‑diuretic combinations, efficacy and safety are comparable, but individual patient factors such as electrolyte balance guide the choice.
How should Irbesartan/Hydrochlorothiazide be stored and handled?+
Store the tablets at ambient temperature, preferably below 25 °C, in the original container to protect them from moisture and light. Keep the product out of reach of children and do not use if the packaging is damaged or the tablets appear discolored.
How is Irbesartan/Hydrochlorothiazide administered?+
The medication is taken orally, usually once daily, with or without food as directed by the prescriber. Swallow the tablet whole with a full glass of water; do not crush or chew unless specifically instructed. Consistent timing each day helps maintain stable blood‑pressure control.
What are the most serious risks associated with Irbesartan/Hydrochlorothiazide?+
Serious adverse events include severe hypotension, acute kidney injury, hyperkalemia, significant electrolyte disturbances (such as hyponatremia), and rare allergic reactions like angioedema. Patients should be monitored for sudden dizziness, reduced urine output, swelling, or rash, and seek medical attention promptly if these occur.
Who should not use Irbesartan/Hydrochlorothiazide?+
The combination is contraindicated in patients with known hypersensitivity to Irbesartan, Hydrochlorothiazide, or any component of the formulation. It should also be avoided in individuals with severe renal impairment, hyperkalemia, or in the second and third trimesters of pregnancy. Clinicians must assess each patient’s medical history before initiating therapy.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Hydrochlorothiazide, Irbesartan
Route
Oral Use
Manufacturer
Actavis Group Ptc Ehf.
Origin
EU

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