Irbesartan/Hydrochlorthiazid Stada

Irbesartan/Hydrochlorothiazide, the active ingredient in Irbesartan/Hydrochlorothiazide Stada, is an angiotensin II receptor blocker / thiazide diuretic presented as a tablet for oral use. It treats hypertension in adult patients. GNH USA supplies Irbesartan/Hydrochlorothiazide Stada as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Irbesartan/Hydrochlorothiazide is used to manage high blood pressure and related cardiovascular conditions.

Essential hypertension: lowers systolic and diastolic blood pressure to reduce cardiovascular risk. Secondary hypertension: helps control blood pressure when it results from another underlying disorder. Hypertension with fluid retention: combines vasodilation and diuresis to reduce excess fluid and pressure.

Common Side Effects: - Dizziness or light‑headedness, especially after the first doses. - Headache or mild fatigue. - Increased urinary frequency due to the diuretic component. - Electrolyte changes such as low potassium or sodium. - Mild gastrointestinal discomfort.

Serious or Rare Side Effects: - Severe dehydration or electrolyte imbalance requiring medical attention. - Acute kidney injury or worsening renal function. - Hyperkalemia, particularly when combined with potassium‑sparing agents. - Anaphylactic or severe allergic reactions. - Blood dyscrasias such as agranulocytosis or thrombocytopenia.

Before initiating therapy, consider the following precautions: - Renal function: assess baseline kidney function and monitor periodically. - Electrolytes: check serum potassium and sodium levels, especially in patients on other diuretics. - Pregnancy: avoid use unless clearly needed, as safety data are limited. - Concomitant drugs: review for potential interactions that may affect blood pressure or electrolytes. - Elderly patients: start at lower doses and monitor for orthostatic hypotension. Store at ambient temperature below 25°C: keep in the original container, protect from moisture and direct sunlight.

Irbesartan/Hydrochlorothiazide may interact with several medicines.

Major Interactions (Avoid): - Potassium‑sparing diuretics or supplements: risk of hyperkalemia. - Lithium: increased lithium levels and toxicity. - ACE inhibitors or other ARBs: additive effects on blood pressure and renal function. - NSAIDs: may reduce antihypertensive efficacy and impair renal function.

Moderate Interactions (Monitor Closely): - Other antihypertensives: may cause excessive hypotension. - Antidiabetic agents: diuretic may affect glucose control. - CYP2C9 inhibitors (e.g., amiodarone): may increase irbesartan plasma levels.