GNH USA

Europe — EMA

Irbesartan Hydrochlorothiazide Zentiva (Hydrochlorothiazide, Irbesartan)

GNH USA supplies Irbesartan Hydrochlorothiazide Zentiva (Irbesartan/Hydrochlorothiazide), an ARB/thiazide antihypertensive for hypertension.

Hydrochlorothiazide, Irbesartan

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What is Hydrochlorothiazide, Irbesartan?

Irbesartan, the active ingredient in Irbesartan Hydrochlorothiazide Zentiva, is an Angiotensin II receptor blocker (ARB) presented as a fixed‑dose oral tablet for oral use. It is indicated for the treatment of hypertension in adult patients and works together with hydrochlorothiazide to improve blood‑pressure control.

GNH USA supplies Irbesartan Hydrochlorothiazide Zentiva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Hydrochlorothiazide, Irbesartan used for?

Irbesartan/Hydrochlorothiazide is an antihypertensive combination that targets elevated blood pressure.

- Hypertension: lowers systolic and diastolic pressure in patients with essential hypertension, helping to reduce cardiovascular risk.

What are the side effects of Hydrochlorothiazide, Irbesartan?

Adverse reactions may vary in frequency and severity.

Common Side Effects: - Dizziness or light‑headedness - Headache - Fatigue or weakness - Increased urination - Electrolyte disturbances such as low potassium - Mild gastrointestinal upset

Serious or Rare Side Effects: - Severe dehydration or electrolyte imbalance - Acute kidney injury or worsening renal function - Hyperkalemia, especially when combined with potassium‑sparing agents - Angioedema or severe allergic reactions - Significant drops in blood pressure (hypotension)

What precautions apply to Hydrochlorothiazide, Irbesartan?

Before initiating therapy, clinicians should consider several safety aspects.

- Blood pressure monitoring: ensure adequate control and avoid hypotension. - Renal function: assess baseline creatinine and eGFR, especially in patients with chronic kidney disease. - Electrolytes: check serum potassium and sodium levels regularly. - Diabetes: monitor glucose as thiazides may affect glycemic control. - Pregnancy and lactation: use only if potential benefit justifies potential risk; safety data are limited. - Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

What does Hydrochlorothiazide, Irbesartan interact with?

Irbesartan/Hydrochlorothiazide may interact with several drug classes.

Major Interactions (Avoid): - Aliskiren in patients with diabetes or renal impairment - Potassium‑sparing diuretics or supplements (risk of hyperkalemia) - Lithium (increased lithium levels and toxicity) - ACE inhibitors or other ARBs (excessive renin‑angiotensin blockade) - NSAIDs (may reduce antihypertensive effect and impair renal function)

Moderate Interactions (Monitor Closely): - Other antihypertensives (additive blood‑pressure lowering) - CYP2C9 inhibitors such as fluconazole (may increase irbesartan levels) - Antidiabetic agents (thiazide‑induced hyperglycemia may require dose adjustment)

Frequently asked questions

What is Irbesartan Hydrochlorothiazide Zentiva used for?+
Irbesartan Hydrochlorothiazide Zentiva is a fixed‑dose oral tablet that combines an angiotensin II receptor blocker with a thiazide diuretic. It is prescribed to lower elevated blood pressure in adults with essential hypertension, helping to reduce the risk of cardiovascular events.
How does Irbesartan work in this combination?+
Irbesartan blocks AT1 receptors, preventing angiotensin II from causing vasoconstriction and aldosterone release. This leads to relaxed blood vessels and reduced fluid retention, contributing to lower blood pressure when used together with hydrochlorothiazide.
What is the usual dose of Irbesartan Hydrochlorothiazide Zentiva?+
The specific dose and dosing schedule are determined by the prescribing clinician based on the patient’s blood‑pressure goals, renal function, and overall health status. The prescriber will select the appropriate strength and frequency.
Is Irbesartan Hydrochlorothiazide safe during pregnancy or breastfeeding?+
Safety data for Irbesartan/HCTZ in pregnancy are limited, and the product is generally not recommended unless the potential benefit outweighs the risk. Breastfeeding mothers should consult their healthcare provider, as the drug may be excreted in milk.
How do I order Irbesartan Hydrochlorothiazide Zentiva from GNH USA?+
To place an order, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.
How does Irbesartan Hydrochlorothiazide compare with other antihypertensive options?+
Compared with monotherapy agents, the Irbesartan/HCTZ combination offers dual mechanisms—vascular relaxation and diuresis—providing more potent blood‑pressure reduction. It may be preferred when a single agent does not achieve target pressures, but clinicians consider individual patient factors and potential side‑effect profiles.
What are the storage and handling requirements for this product?+
Store the tablets at ambient temperature, below 25 °C, in the original packaging. Keep them away from moisture, heat and direct sunlight to maintain stability and potency throughout the shelf life.
How is Irbesartan Hydrochlorothiazide Zentiva administered?+
The medication is taken orally, usually once daily, with or without food, as directed by the prescriber. Swallow the tablet whole with a full glass of water; do not crush or chew unless specifically instructed.
What are the most serious risks associated with this medication?+
Serious risks include severe dehydration, electrolyte imbalances (especially low potassium), acute kidney injury, hyperkalemia, and rare cases of angioedema. Patients should report symptoms such as rapid weight loss, muscle weakness, swelling of the face or throat, or a sudden drop in blood pressure.
Who should not use Irbesartan Hydrochlorothiazide Zentiva?+
The combination should be avoided in patients with known hypersensitivity to irbesartan, hydrochlorothiazide, or any component of the formulation. It is also contraindicated in severe renal impairment, anuria, and in patients with a history of angioedema related to ARB therapy.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Hydrochlorothiazide, Irbesartan
Route
Oral Use
Manufacturer
Zentiva, K.S.
Origin
EU

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