Irbesartan/Hydrochlorothiazide Teva (Hydrochlorothiazide, Irbesartan)

Irbesartan/Hydrochlorothiazide, the active ingredient in Irbesartan/Hydrochlorothiazide Teva, is an angiotensin II receptor blocker and thiazide diuretic presented as an oral tablet for oral use. It treats hypertension in adult patients. GNH USA supplies Irbesartan/Hydrochlorothiazide Teva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Irbesartan/Hydrochlorothiazide is used to manage hypertension by targeting the renin‑angiotensin‑aldosterone system and promoting diuresis.

Hypertension: lowers elevated blood pressure in adults. Essential hypertension: improves blood pressure control when monotherapy is insufficient. High blood pressure with fluid retention: adds a diuretic effect to enhance antihypertensive response.

Common Side Effects: - Dizziness or light‑headedness. - Headache. - Fatigue or weakness. - Increased urination. - Electrolyte disturbances such as low potassium. - Mild gastrointestinal upset.

Serious or Rare Side Effects: - Severe dehydration or electrolyte imbalance. - Acute kidney injury. - Hyperkalemia. - Angioedema or severe swelling. - Significant hypotension. - Pancreatitis (rare).

Before initiating therapy, consider the following precautions.

Monitor blood pressure regularly: ensure therapeutic response and avoid excessive lowering. Check serum electrolytes: especially potassium and sodium levels. Assess renal function: adjust therapy if creatinine clearance is reduced. Avoid use in severe hepatic impairment: limited data on safety. Use caution in diabetic patients: diuretic may affect glucose control. Store at below 25°C: keep in the original container, protect from moisture and light.

Irbesartan/Hydrochlorothiazide may interact with several medicines; review patient medication lists.

Major Interactions (Avoid): - Aliskiren in diabetic patients: risk of hypotension and renal impairment. - Potassium‑sparing diuretics or supplements: may cause hyperkalemia. - ACE inhibitors or other ARBs: additive blood‑pressure lowering effect. - Lithium: increased lithium levels and toxicity. - NSAIDs: may blunt antihypertensive effect and affect renal function.

Moderate Interactions (Monitor Closely): - Other antihypertensives: monitor for excessive hypotension. - Antidiabetic agents: diuretic may raise blood glucose. - CYP2C9 inhibitors (e.g., fluconazole): may increase hydrochlorothiazide levels. - Antacids containing aluminum or magnesium: may reduce absorption of irbesartan. - Loop diuretics: monitor electrolyte balance.