Irbesartan/Hydrochlorothiazide Teva

Irbesartan and Hydrochlorothiazide, the active ingredients in Irbesartan/Hydrochlorothiazide Teva, are an angiotensin II receptor blocker and a thiazide diuretic presented as a fixed‑dose oral tablet for oral use. They are used to treat hypertension, often in patients who need additional blood pressure control.

GNH USA supplies Irbesartan/Hydrochlorothiazide Teva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Irbesartan/Hydrochlorothiazide is indicated for hypertension, acting on the renin‑angiotensin‑aldosterone system and promoting diuresis. - Hypertension: provides combined blood pressure reduction in patients requiring dual therapy. - Edema associated with hypertension: assists in fluid removal and blood pressure control. - High blood pressure in chronic kidney disease: offers effective control while addressing volume overload.

Common Side Effects: - Dizziness: sensation of light‑headedness, especially after standing. - Headache: mild to moderate pain in the head region. - Fatigue: feeling unusually tired or weak. - Increased urination: more frequent need to void. - Low potassium: reduced serum potassium levels. - Hyperuricemia: elevated uric acid in blood.

Serious or Rare Side Effects: - Severe dehydration: marked fluid loss requiring medical attention. - Acute kidney injury: sudden decline in renal function. - Hyperkalemia: dangerously high potassium levels. - Severe allergic reaction: rash, swelling, or anaphylaxis. - Pancreatitis: inflammation of the pancreas. - Blood dyscrasias: abnormal blood cell counts.

Before initiating therapy, clinicians should consider several safety aspects. - Monitor renal function: assess serum creatinine and eGFR regularly. - Assess electrolyte balance: watch for hypo‑ or hyperkalemia. - Evaluate volume status: avoid use in severe dehydration. - Use caution in pregnancy: contraindicated in second and third trimesters. - Avoid in patients with anuria or severe renal impairment. - Store at ambient temperature: keep in the original pack, protect from moisture.

Irbesartan/Hydrochlorothiazide may interact with several medicines. Major Interactions (Avoid): - Aliskiren (in diabetes): increased risk of renal impairment. - Potassium‑sparing diuretics: risk of hyperkalemia. - ACE inhibitors: additive effect on potassium and renal function. - NSAIDs: may reduce antihypertensive efficacy and affect kidneys. - Lithium: increased lithium concentrations. Moderate Interactions (Monitor Closely): - Other antihypertensives: may cause excessive blood pressure lowering. - Antidiabetic agents: may require dose adjustment. - CYP3A4 inhibitors (e.g., ketoconazole): increase irbesartan levels. - Antacids containing aluminum/magnesium: may reduce irbesartan absorption. - High‑dose NSAIDs: heightened risk of renal dysfunction.