Irbesartan/Hydrochlorothiazide Brown & Burk (Hydrochlorothiazide, Irbesartan)

Irbesartan/Hydrochlorothiazide, the active ingredient in Irbesartan/Hydrochlorothiazide Brown & Burk, is an Angiotensin II receptor blocker (ARB) / Thiazide diuretic presented as an oral tablet for systemic use. It is used to lower high blood pressure in adult patients.

GNH USA supplies Irbesartan/Hydrochlorothiazide Brown & Burk as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Irbesartan/Hydrochlorothiazide is indicated for the management of hypertension, acting on the renin‑angiotensin‑aldosterone system and renal sodium handling. - Essential hypertension: reduces systolic and diastolic blood pressure to target levels. - Secondary hypertension: assists in controlling blood pressure when caused by another underlying condition. - General hypertension: provides long‑term blood pressure control in adult patients.

Common Side Effects: - Dizziness or light‑headedness - Headache - Fatigue or weakness - Increased urination - Electrolyte disturbances (e.g., low potassium) - Mild gastrointestinal upset

Serious or Rare Side Effects: - Severe dehydration or electrolyte imbalance - Acute kidney injury or worsening renal function - Hyperkalemia or severe hyponatremia - Angio‑edema or severe allergic reaction - Liver function abnormalities - Significant drops in blood pressure (hypotension).

Before initiating therapy, consider the following precautions: - Monitor blood pressure regularly: ensure therapeutic response and avoid hypotension. - Assess renal function: adjust therapy if creatinine clearance is reduced. - Check electrolytes: especially potassium and sodium levels. - Use caution in elderly patients: increased sensitivity to blood pressure changes. - Avoid in patients with severe hepatic impairment: limited data on safety. - Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Irbesartan/Hydrochlorothiazide may interact with several medicines. Review patient medication lists carefully. Major Interactions (Avoid): - Aliskiren: combined use can increase risk of renal dysfunction and hyperkalemia. - Potassium‑sparing diuretics or supplements: may cause dangerous hyperkalemia. - Lithium: can raise lithium levels, leading to toxicity. - ACE inhibitors or other ARBs: additive effects on blood pressure and potassium. - NSAIDs (high dose): may blunt antihypertensive effect and impair renal function.

Moderate Interactions (Monitor Closely): - Other antihypertensives: may require dose adjustment to prevent hypotension. - Digoxin: monitor serum levels as diuretic‑induced electrolyte changes can affect toxicity. - Antidiabetic agents: diuretic‑induced changes in glucose may require dose modification. - Corticosteroids: may increase sodium retention, counteracting diuretic effect. - Antimicrobials (e.g., trimethoprim): can raise potassium levels.