Irbesartan/Hydrochlorothiazid Micro Labs (Hydrochlorothiazide, Irbesartan)

Irbesartan, the active ingredient in Irbesartan/Hydrochlorothiazide Micro Labs, is an angiotensin II receptor blocker (ARB) presented as a combination oral tablet for oral use. It treats hypertension by lowering blood pressure in adult patients who require antihypertensive therapy.

GNH USA supplies Irbesartan/Hydrochlorothiazide Micro Labs as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The product complies with EU regulatory standards and is manufactured by Micro Labs. It is distributed under strict quality assurance protocols.

Irbesartan/Hydrochlorothiazide is used to manage hypertension, a condition characterized by elevated arterial pressure.

Hypertension: reduces systolic and diastolic blood pressure in patients with primary hypertension. Essential hypertension: helps achieve target blood pressure levels as part of combination therapy. Hypertension with fluid retention: assists in controlling blood pressure while promoting diuresis to reduce excess fluid.

The combination may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects: - Dizziness or light‑headedness. - Headache. - Increased urination. - Electrolyte disturbances such as low potassium.

Serious or Rare Side Effects: - Severe allergic reaction (anaphylaxis, skin rash). - Acute kidney injury or worsening renal function. - Significant drop in blood pressure (hypotension).

When prescribing Irbesartan/Hydrochlorothiazide, clinicians should consider several safety measures. - Monitor blood pressure regularly: ensure therapeutic targets are met without excessive lowering. - Assess renal function before and during therapy: adjust dosing if renal impairment is present. - Check serum electrolytes, especially potassium: correct imbalances promptly. - Use caution in patients with hepatic impairment: monitor liver function tests. - Adjust dose in elderly or those with reduced renal function: start at lower doses. - Store at room temperature: keep in the original pack, protect from moisture.

Irbesartan/Hydrochlorothiazide can interact with other medicines, requiring attention to avoid reduced efficacy or increased toxicity.

Major Interactions (Avoid): - Potassium‑sparing diuretics or potassium supplements: risk of hyperkalemia. - ACE inhibitors or other ARBs (dual renin‑angiotensin blockade): may cause renal dysfunction. - Lithium therapy: increased risk of lithium toxicity.

Moderate Interactions (Monitor Closely): - NSAIDs: may blunt antihypertensive effect. - CYP2C9 inhibitors such as fluconazole: may raise irbesartan plasma levels.